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Institution

Brown University

EducationProvidence, Rhode Island, United States
About: Brown University is a education organization based out in Providence, Rhode Island, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 35778 authors who have published 90896 publications receiving 4471489 citations. The organization is also known as: brown.edu & Brown.


Papers
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Journal ArticleDOI
TL;DR: This review critically assesses the hypothesis that the reinforcing effect of virtually all drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system and indicates that increased dopamine transmission is clearly both necessary and sufficient to promote psychostimulant reinforcement.

925 citations

Journal ArticleDOI
08 Apr 2010-Nature
TL;DR: It is shown that dislocation nucleation governs the strength of nano-twinned materials, resulting in their softening below a critical twin thickness, and the critical twin-boundary spacing and the maximum strength depend on the grain size.
Abstract: In conventional metals, there is plenty of space for dislocations-line defects whose motion results in permanent material deformation-to multiply, so that the metal strengths are controlled by dislocation interactions with grain boundaries(1,2) and other obstacles(3,4). For nano-structured materials, in contrast, dislocation multiplication is severely confined by the nanometre-scale geometries so that continued plasticity can be expected to be source-controlled. Nano-grained polycrystalline materials were found to be strong but brittle(5-9), because both nucleation and motion of dislocations are effectively suppressed by the nanoscale crystallites. Here we report a dislocation-nucleation-controlled mechanism in nano-twinned metals(10,11) in which there are plenty of dislocation nucleation sites but dislocation motion is not confined. We show that dislocation nucleation governs the strength of such materials, resulting in their softening below a critical twin thickness. Large-scale molecular dynamics simulations and a kinetic theory of dislocation nucleation in nano-twinned metals show that there exists a transition in deformation mechanism, occurring at a critical twin-boundary spacing for which strength is maximized. At this point, the classical Hall-Petch type of strengthening due to dislocation pile-up and cutting through twin planes switches to a dislocation-nucleation-controlled softening mechanism with twin-boundary migration resulting from nucleation and motion of partial dislocations parallel to the twin planes. Most previous studies(12,13) did not consider a sufficient range of twin thickness and therefore missed this strength-softening regime. The simulations indicate that the critical twin-boundary spacing for the onset of softening in nano-twinned copper and the maximum strength depend on the grain size: the smaller the grain size, the smaller the critical twin-boundary spacing, and the higher the maximum strength of the material.

924 citations

Journal ArticleDOI
James R. Rice1
TL;DR: In this paper, it was shown that if the displacement field and stress intensity factor are known as functions of crack length for any symmetrical load system acting on a linear elastic body in plane strain, then the stress intensity factors for any other symmetric load system whatsoever on the same body may be directly determined.

923 citations

Journal ArticleDOI
TL;DR: Improved basic care driven by education and quality-improvement programmes offers the best hope of increasing favourable outcomes in sepsis.

919 citations

Journal ArticleDOI
TL;DR: In this paper, it was shown that a small amplitude disturbance propagates through a series of cars in the manner described by linear theories, except that the dependence of the wave velocity on the car velocity causes an accleration wave to spread as it propagates and a deceleration wave forming a stable shock.
Abstract: It is assumed that the velocity of a car at time t is some nonlinear function of the spacial headway at time t-Δ, so the equations of motion for a sequence of cars consists of a set of differential-difference equations. There is a special family of velocity-headway relations that agrees well with experimental data for steady flow, and that also gives differential equations which for Δ = 0 can be solved explicitly. Some exact solutions of these equations show that a small amplitude disturbance propagates through a series of cars in the manner described by linear theories except that the dependence of the wave velocity on the car velocity causes an accleration wave to spread as it propagates and a deceleration wave to form a stable shock. These conclusions are then shown to hold for quite general types of velocity-headway relations, and to yield a theory that in certain limiting cases gives all the results of the linear car-following theories and in other cases all the features of the nonlinear continuum theories, plus a detailed picture of the shock structure.

918 citations


Authors

Showing all 36143 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
Robert Langer2812324326306
Robert M. Califf1961561167961
Eric J. Topol1931373151025
Joan Massagué189408149951
Joseph Biederman1791012117440
Gonçalo R. Abecasis179595230323
James F. Sallis169825144836
Steven N. Blair165879132929
Charles M. Lieber165521132811
J. S. Lange1602083145919
Christopher J. O'Donnell159869126278
Charles M. Perou156573202951
David J. Mooney15669594172
Richard J. Davidson15660291414
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023126
2022591
20215,550
20205,321
20194,806
20184,462