Institution
Brown University
Education•Providence, Rhode Island, United States•
About: Brown University is a education organization based out in Providence, Rhode Island, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 35778 authors who have published 90896 publications receiving 4471489 citations. The organization is also known as: brown.edu & Brown.
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University of Tasmania1, National Drug and Alcohol Research Centre2, Brown University3, University of Bristol4, University at Buffalo5, University College London6, King's College London7, University of Queensland8, University of Adelaide9, Institute for Health Metrics and Evaluation10, Centre for Mental Health11, University of New South Wales12
TL;DR: In 2015 alcohol use and tobacco smoking use between them cost the human population more than a quarter of a billion disability-adjusted life years, with illicit drugs costing further tens of millions.
Abstract: Amy Peacock, Janni Leung, Sarah Larney, Samantha Colledge, Matthew Hickman, Jurgen Rehm, Gary A. Giovino, Robert West, Wayne Hall, Paul Griffiths, Robert Ali, Linda Gowing, John Marsden, Alize J. Ferrari, Jason Grebely, Michael Farrell and Louisa Degenhardt
623 citations
Northwestern University1, George Washington University2, National Institutes of Health3, University of Alabama at Birmingham4, University of Utah5, Stanford University6, Columbia University7, Brown University8, University of Texas Medical Branch9, University of North Carolina at Chapel Hill10, University of Texas Health Science Center at Houston11, Ohio State University12, MetroHealth13, University of Texas Southwestern Medical Center14, University of Colorado Denver15, University of Pennsylvania16, Duke University17, University of Pittsburgh18, Washington University in St. Louis19
TL;DR: Induction of labor at 39 weeks in low‐risk nulliparous women did not result in a significantly lower frequency of a composite adverse perinatal outcome, but it did result in less frequency of cesarean delivery.
Abstract: Background The perinatal and maternal consequences of induction of labor at 39 weeks among low-risk nulliparous women are uncertain. Methods In this multicenter trial, we randomly assigned...
623 citations
622 citations
TL;DR: In this article, the authors studied the effect of collision centrality on the transverse momentum of PbPb collisions at the LHC with a data sample of 6.7 inverse microbarns.
Abstract: Jet production in PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV was studied with the CMS detector at the LHC, using a data sample corresponding to an integrated luminosity of 6.7 inverse microbarns. Jets are reconstructed using the energy deposited in the CMS calorimeters and studied as a function of collision centrality. With increasing collision centrality, a striking imbalance in dijet transverse momentum is observed, consistent with jet quenching. The observed effect extends from the lower cut-off used in this study (jet transverse momentum = 120 GeV/c) up to the statistical limit of the available data sample (jet transverse momentum approximately 210 GeV/c). Correlations of charged particle tracks with jets indicate that the momentum imbalance is accompanied by a softening of the fragmentation pattern of the second most energetic, away-side jet. The dijet momentum balance is recovered when integrating low transverse momentum particles distributed over a wide angular range relative to the direction of the away-side jet.
621 citations
TL;DR: An empirical relation between the degree of bending and the altered electrophoretic mobility in polyacrylamide gels that allows estimation of protein-induced bends is generated.
Abstract: Protein-induced DNA bending is an important element in the structure of many protein-DNA complexes, including those involved in replication, transcription, and recombination. To understand these structures, the path followed by the DNA in each complex must be established. We have generated an empirical relation between the degree of bending and the altered electrophoretic mobility in polyacrylamide gels that allows estimation of protein-induced bends. This technique has been used to analyze 17 different protein-DNA complexes formed by six proteins including the four proteins involved in lambda site-specific recombination. The simplicity of this technique should make it useful in estimating angles for the construction of models of protein-DNA complexes and readily applicable to many systems where questions of higher-order structure are important for understanding function.
621 citations
Authors
Showing all 36143 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Walter C. Willett | 334 | 2399 | 413322 |
| Robert Langer | 281 | 2324 | 326306 |
| Robert M. Califf | 196 | 1561 | 167961 |
| Eric J. Topol | 193 | 1373 | 151025 |
| Joan Massagué | 189 | 408 | 149951 |
| Joseph Biederman | 179 | 1012 | 117440 |
| Gonçalo R. Abecasis | 179 | 595 | 230323 |
| James F. Sallis | 169 | 825 | 144836 |
| Steven N. Blair | 165 | 879 | 132929 |
| Charles M. Lieber | 165 | 521 | 132811 |
| J. S. Lange | 160 | 2083 | 145919 |
| Christopher J. O'Donnell | 159 | 869 | 126278 |
| Charles M. Perou | 156 | 573 | 202951 |
| David J. Mooney | 156 | 695 | 94172 |
| Richard J. Davidson | 156 | 602 | 91414 |