Institution
Fred Hutchinson Cancer Research Center
Nonprofit•Cape Town, South Africa•
About: Fred Hutchinson Cancer Research Center is a nonprofit organization based out in Cape Town, South Africa. It is known for research contribution in the topics: Population & Transplantation. The organization has 12322 authors who have published 30954 publications receiving 2288772 citations. The organization is also known as: Fred Hutch & The Hutch.
Topics: Population, Transplantation, Cancer, Breast cancer, Prostate cancer
Papers published on a yearly basis
Papers
More filters
TL;DR: Chronic graft versus host disease (GvHD) continues to be a significant problem in the allogeneic stem cell transplant setting and, as the authors continue to use alternative stem cell sources and attempt to modulate the immune system to increase an anti-tumour effect, they will probably see rising numbers of patients with this complication.
843 citations
TL;DR: A multivariate analysis controlling for autologous marrow grafting showed that the dose of TBI was the only statistically significant predictor of grades III-IV RRT, and those patients who developed grade III RRT were unlikely to survive 100 days from transplant, though not all deaths could be attributed to RRT.
Abstract: Bone marrow transplantation is associated with significant morbidity and mortality, some of which is due to high-dose chemoradiotherapy. In order to quantitate toxicity that was felt to be due to the preparative regimen (termed regimen-related toxicity [RRT]), a system was developed in which toxicities were graded from 0 (none) to 4 (fatal). One hundred ninety-five patients who underwent marrow transplantation for leukemia were studied retrospectively to determine whether toxicities that were clinically felt to be due to the preparative regimen were influenced by other factors such as disease status, graft-versus-host disease (GVHD) prophylaxis, and allogenicity. All patients developed grade I toxicity in at least one organ, and 30 developed grades III-IV (life-threatening or fatal) RRT. RRT was more common in relapsed patients v remission patients (P = .04), in those receiving 15.75 Gy total body irradiation (TBI) v 12.0 Gy TBI (P = .028), and in those receiving allogeneic marrow v autologous marrow (P = .0029). Autologous marrow recipients did not develop grades III-IV toxicity in this study. A multivariate analysis controlling for autologous marrow grafting showed that the dose of TBI was the only statistically significant predictor of grades III-IV RRT. Those patients who developed grade III RRT were unlikely to survive 100 days from transplant, though not all deaths could be attributed to RRT. Patients who developed grade II toxicity in three or more organs were more likely to die within 100 days than those developing grade II toxicity in two or less organs (P = .0027). This system was generally able to distinguish RRT from other toxicities observed in marrow recipients.
841 citations
TL;DR: Property of the major types of histone modification in the context of their associated biological processes are considered to view them in light of the cellular mechanisms that regulate nucleosome dynamics.
Abstract: The properties of nucleosomes can be altered in various ways, including by covalent modification of histones. In this Review, the known properties of key histone modifications and the biological processes to which they are linked are examined to place the modifications in the context of nucleosome dynamics—that is, processes in which nucleosomes are translocated, unwrapped, evicted or replaced.
840 citations
TL;DR: DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae, but it is found that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of the nucleosome core.
840 citations
University of Cologne1, University of Freiburg2, Fred Hutchinson Cancer Research Center3, University of Regensburg4, University of Liverpool5, Lund University6, University of Basel7, Discovery Institute8, Imperial College London9, Northwestern University10, National Institutes of Health11, Stanford University12, University of Manchester13, French Institute of Health and Medical Research14, Washington University in St. Louis15, Yokohama City University16, Karolinska Institutet17, Vanderbilt University18, Harvard University19, Max Planck Society20, Osaka University21, University of Copenhagen22, Thomas Jefferson University23, University of Helsinki24, University of Erlangen-Nuremberg25, Rutgers University26
TL;DR: A new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers is introduced, which is introduced for laminin trimers.
836 citations
Authors
Showing all 12368 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Walter C. Willett | 334 | 2399 | 413322 |
| Robert Langer | 281 | 2324 | 326306 |
| Meir J. Stampfer | 277 | 1414 | 283776 |
| JoAnn E. Manson | 270 | 1819 | 258509 |
| David J. Hunter | 213 | 1836 | 207050 |
| Peer Bork | 206 | 697 | 245427 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Ruedi Aebersold | 182 | 879 | 141881 |
| Bruce M. Psaty | 181 | 1205 | 138244 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| David Baker | 173 | 1226 | 109377 |
| Frederick W. Alt | 171 | 577 | 95573 |
| Lily Yeh Jan | 162 | 467 | 73655 |
| Yuh Nung Jan | 162 | 460 | 74818 |
| Charles N. Serhan | 158 | 728 | 84810 |