Georgia State University

About: Georgia State University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13988 authors who have published 35895 publications receiving 1164332 citations. The organization is also known as: GSU & Georgia State.

Drugs that target dynamic microtubules: a new molecular perspective.

Abstract: Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is a wide variety of compounds currently in clinical use and in development that act as antimitotic agents by altering microtubule dynamics. Although these diverse molecules are known to affect microtubule dynamics upon binding to one of the three established drug domains (taxane, vinca alkaloid, or colchicine site), the exact mechanism by which each drug works is still an area of intense speculation and research. In this study, we review the effects of microtubule-binding chemotherapeutic agents from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of microtubule assembly or disassembly. These “biological vectors” can thus be used as a spatiotemporal context to describe molecular mechanisms by which microtubule-targeting drugs work.

Public Service Motivation and Job Performance Evidence from the Federal Sector

Abstract: Perry and Wise (1990) argued that people with high public service motivation (PSM) are more likely than others to choose government jobs, to perform better on the job, and to respond more to nonutilitarian incentives once in government. Using multiple regression and logit analyses on responses by 35,000 federal, white-collar employees to the 1991 Survey of Federal Employees and the 1996 Merit Principles Survey, this article tests the link between PSM and job performance in the federal service. There is mixed evidence on whether PSM positively affected grades and performance ratings, clearer evidence that employees who expected to receive a material reward for exceptional performance attained higher grades and performance ratings, and no evidence that the link between material rewards and performance mattered any less to those with high PSM.

Subtypes of reading disability: Variability around a phonological core.

Abstract: Eight measures of cognitive and language functions in 232 children were subjected to multiple methods of cluster analysis in an effort to identify subtypes of reading disability. Clustering yielded 9 reliable subtypes representing 90% of the sample, including 2 nondisabled subtypes, and 7 reading-disabled subtypes. Of the reading-disabled subtypes, 2 were globally deficient in language skills, whereas 4 of the 5 specific reading-disabled subtypes displayed a relative weakness in phonological awareness and variations in rapid serial naming and verbal short-term memory. The remaining disabled subtype was impaired on verbal and nonverbal measures associated with rate of processing, including rate and accuracy of oral reading. Studies showed evidence for discriminative validity among the 7 reading-disabled subtypes. Results support the view that children with reading disability usually display impairments on phonological awareness measures, with discriminative variability on other measures involving phonological processing, language, and cognitive skills.

What Determines the Value of Life: A Meta‐Analysis

Abstract: A large literature has developed in which labor market contracts are used to estimate the value of a statistical life (VSL). Reported estimates of the VSL vary substantially, from less than $100,000 to more than $25 million. This research uses meta-analysis to quantitatively assess the VSL literature. Results from existing studies are pooled to identify the systematic relationships between VSL estimates and each study's particular features, such as the sample composition and research methods. This meta-analysis suggests that a VSL range of approximately $1.5 million to $2.5 million (in 1998 dollars) is what can be reasonably inferred from past labor-market studies when “best practice” assumptions are invoked. This range is considerably below many previous qualitative reviews of this literature. © 2002 by the Association for Public Policy Analysis and Management.