University at Buffalo

About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.

Attachment Styles, Gender and Parental Problem Drinking:

Abstract: Bartholomew's (1990) four-category typology of adult attachment styles was compared with Hazan & Shaver's (1987) three-category typology in terms of three substantive issues. First, the same two dimensions were found to underlie both typologies, and the Bartholomew and Hazan & Shaver measures corresponded as predicted. Second, there were no gender differences on Hazan & Shaver's measure, in line with previous studies, but there were gender differences on Bartholomew's measure, especially in her two avoidant categories. More males than females were dismissing avoidants; more females than males were fearful avoidants. Third, a hypothesis advanced by Latty-Mann & Davis (1988) was confirmed. Adult children of alcoholics scored high on both avoidant and anxious-ambivalent scales of Hazan & Shaver's measure, and fell predominantly into Bartholomew's fearful-avoidant category, suggesting that at least some fearful adults are grown-up versions of the `disorganized, disoriented' children identified by Crittenden (...

Effectiveness of St John's wort in major depression: A randomized controlled trial

Abstract: ContextExtracts of St John's wort are widely used to treat depression. Although more than 2 dozen clinical trials have been conducted with St John's wort, most have significant flaws in design and do not enable meaningful interpretation.ObjectiveTo compare the efficacy and safety of a standardized extract of St John's wort with placebo in outpatients with major depression.Design and SettingRandomized, double-blind, placebo-controlled clinical trial conducted between November 1998 and January 2000 in 11 academic medical centers in the United States.ParticipantsTwo hundred adult outpatients (mean age, 42.4 years; 67.0% female; 85.9% white) diagnosed as having major depression and having a baseline Hamilton Rating Scale for Depression (HAM-D) score of at least 20.InterventionParticipants completed a 1-week, single-blind run-in of placebo, then were randomly assigned to receive either St John's wort extract (n = 98; 900 mg/d for 4 weeks, increased to 1200 mg/d in the absence of an adequate response thereafter) or placebo (n = 102) for 8 weeks.Main Outcome MeasuresThe primary outcome measure was rate of change on the HAM-D over the treatment period. Secondary measures included the Beck Depression Inventory (BDI), Hamilton Rating Scale for Anxiety (HAM-A), the Global Assessment of Function (GAF) scale, and the Clinical Global Impression–Severity and –Improvement scales (CGI-S and CGI-I).ResultsThe random coefficient analyses for the HAM-D, HAM-A, CGI-S, and CGI-I all showed significant effects for time but not for treatment or time-by-treatment interaction (for HAM-D scores, P<.001, P = .16, and P = .58, respectively). Analysis of covariance showed nonsignificant effects for BDI and GAF scores. The proportion of participants achieving an a priori definition of response did not differ between groups. The number reaching remission of illness was significantly higher with St John's wort than with placebo (P = .02), but the rates were very low in the full intention-to-treat analysis (14/98 [14.3%] vs 5/102 [4.9%], respectively). St John's wort was safe and well tolerated. Headache was the only adverse event that occurred with greater frequency with St John's wort than placebo (39/95 [41%] vs 25/100 [25%], respectively).ConclusionIn this study, St John's wort was not effective for treatment of major depression.

Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients.

Abstract: Background and Aims:Elevated residual volumes (RV), considered a marker for the risk of aspiration, are used to regulate the delivery of enteral tube feeding. We designed this prospective study to validate such use.Methods:Critically ill patients undergoing mechanical ventilation in the medical, cor

Gibbs-Duhem integration: a new method for direct evaluation of phase coexistence by molecular simulation

Abstract: A method that combines the best elements of thermodynamic integration and the Gibbs ensemble technique is proposed for the direct evaluation of phase equilibria by molecular simulation. Given the conditions of coexistence at a single state point, simultaneous but independent NPT simulations of each phase are performed in succession along the saturation line. In each simulation, the pressure is adjusted to satisfy chemical potential equality according to the Gibbs-Duhem equation. Each coexistence point is determined by just one simulation, and particle insertions are never performed or attempted. Vapourliquid coexistence for the Lennard-Jones model is evaluated, and extensions are discussed.