Institution
University of Cagliari
Education•Cagliari, Italy•
About: University of Cagliari is a education organization based out in Cagliari, Italy. It is known for research contribution in the topics: Population & Dopamine. The organization has 11029 authors who have published 29046 publications receiving 771023 citations. The organization is also known as: Università degli Studi di Cagliari & Universita degli Studi di Cagliari.
Topics: Population, Dopamine, Dopaminergic, Context (language use), Medicine
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the spontaneous polarization, dynamical Born charges, and piezoelectric constants of the III-V nitrides AlN, GaN, and InN are studied ab initio using the Berry-phase approach to polarization in solids.
Abstract: The spontaneous polarization, dynamical Born charges, and piezoelectric constants of the III-V nitrides AlN, GaN, and InN are studied ab initio using the Berry-phase approach to polarization in solids. The piezoelectric constants are found to be up to ten times larger than in conventional III-V and II-VI semiconductor compounds, and comparable to those of ZnO. Further properties at variance with those of conventional III-V compounds are the sign of the piezoelectric constants (positive as in II-VI compounds) and the very large spontaneous polarization.
2,785 citations
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TL;DR: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva).
Abstract: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems, as established by test beam measurements and simulation studies, is described.
2,286 citations
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University of Cambridge1, University of Birmingham2, Southampton General Hospital3, Humboldt University of Berlin4, Karolinska Institutet5, University of Cagliari6, United States Military Academy7, Baylor College of Medicine8, Wellcome Trust Sanger Institute9, University of Helsinki10, Northern General Hospital11, University of Bristol12, University of Oslo13, Norwegian Institute of Public Health14, Queen's University Belfast15, Merck & Co.16
TL;DR: In this article, the authors identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4) as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes.
Abstract: Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)—which encodes a vital negative regulatory molecule of the immune system—as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes. In humans, disease susceptibility was mapped to a non-coding 6.1?kb 3′ region of CTLA4, the common allelic variation of which was correlated with lower messenger RNA levels of the soluble alternative splice form of CTLA4. In the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA-4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80/CD86 ligand-binding domain. Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction.
2,173 citations
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TL;DR: Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance.
Abstract: We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10−17; including ADGC data, meta P = 5.0 × 10−21) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10−14; including ADGC data, meta P = 1.2 × 10−16) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10−4; including ADGC data, meta P = 8.6 × 10−9), CD33 (GERAD+, P = 2.2 × 10−4; including ADGC data, meta P = 1.6 × 10−9) and EPHA1 (GERAD+, P = 3.4 × 10−4; including ADGC data, meta P = 6.0 × 10−10).
1,771 citations
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23 Sep 2013TL;DR: This work presents a simple but effective gradient-based approach that can be exploited to systematically assess the security of several, widely-used classification algorithms against evasion attacks.
Abstract: In security-sensitive applications, the success of machine learning depends on a thorough vetting of their resistance to adversarial data. In one pertinent, well-motivated attack scenario, an adversary may attempt to evade a deployed system at test time by carefully manipulating attack samples. In this work, we present a simple but effective gradient-based approach that can be exploited to systematically assess the security of several, widely-used classification algorithms against evasion attacks. Following a recently proposed framework for security evaluation, we simulate attack scenarios that exhibit different risk levels for the classifier by increasing the attacker's knowledge of the system and her ability to manipulate attack samples. This gives the classifier designer a better picture of the classifier performance under evasion attacks, and allows him to perform a more informed model selection (or parameter setting). We evaluate our approach on the relevant security task of malware detection in PDF files, and show that such systems can be easily evaded. We also sketch some countermeasures suggested by our analysis.
1,667 citations
Authors
Showing all 11160 results
Name | H-index | Papers | Citations |
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Herbert W. Marsh | 152 | 646 | 89512 |
Michele Parrinello | 133 | 637 | 94674 |
Dafna D. Gladman | 129 | 1036 | 75273 |
Peter J. Anderson | 120 | 966 | 63635 |
Alessandro Vespignani | 118 | 419 | 63824 |
C. Patrignani | 117 | 1754 | 110008 |
Hermine Katharina Wöhri | 116 | 629 | 55540 |
Francesco Muntoni | 115 | 963 | 52629 |
Giancarlo Comi | 109 | 961 | 54270 |
Giorgio Parisi | 108 | 941 | 60746 |
Luca Benini | 101 | 1453 | 47862 |
Alessandro Cardini | 101 | 1288 | 53804 |
Nicola Serra | 100 | 1042 | 46640 |
Jurg Keller | 99 | 389 | 35628 |
Giulio Usai | 97 | 517 | 39392 |