Institution
University of Copenhagen
Education•Copenhagen, Denmark•
About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Medicine. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.
Topics: Population, Medicine, Galaxy, Diabetes mellitus, Cancer
Papers published on a yearly basis
Papers
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TL;DR: The crystal structure of horseradish peroxidase isozyme C (HRPC) has been solved to 2.15 Å resolution and the key residue involved in direct interactions with aromatic donor molecules is identified, predicted to be important for the ability of HRPC to bind aromatic substrates.
Abstract: The crystal structure of horseradish peroxidase isozyme C (HRPC) has been solved to 2.15 A resolution. An important feature unique to the class III peroxidases is a long insertion, 34 residues in HRPC, between helices F and G. This region, which defines part of the substrate access channel, is not present in the core conserved fold typical of peroxidases from classes I and II. Comparison of HRPC and peanut peroxidase (PNP), the only other class III (higher plant) peroxidase for which an X-ray structure has been completed, reveals that the structure in this region is highly variable even within class III. For peroxidases of the HRPC type, characterized by a larger FG insertion (seven residues relative to PNP) and a shorter F′ helix, we have identified the key residue involved in direct interactions with aromatic donor molecules. HRPC is unique in having a ring of three peripheral Phe residues, 142, 68 and 179. These guard the entrance to the exposed haem edge. We predict that this aromatic region is important for the ability of HRPC to bind aromatic substrates.
652 citations
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Lanzhou University1, Beijing Genomics Institute2, Chinese Academy of Sciences3, Konkuk University4, University of Illinois at Urbana–Champaign5, Aberystwyth University6, University of California, Davis7, Fudan University8, Utrecht University9, Cardiff University10, University of Copenhagen11, Sichuan University12
TL;DR: Positively selected and rapidly evolving genes in the yak lineage are found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism, which may have important implications for understanding adaptation to high altitude in other animal species and for Hypoxia-related diseases in humans.
Abstract: Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
652 citations
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TL;DR: About half of patients with UC will be in remission at any time, although 90% have an intermittent course, and relapses are unpredictable except that disease activity in foregoing years indicates with 70%-80% probability that the disease will continue the following year.
651 citations
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TL;DR: In this paper, the effects of stochastic wind and load on the unit commitment and dispatch of power systems with high levels of wind power are examined, by comparing the costs, planned operation and performance of the schedules produced.
Abstract: The stochastic nature of wind alters the unit commitment and dispatch problem. By accounting for this uncertainty when scheduling the system, more robust schedules are produced, which should, on average, reduce expected costs. In this paper, the effects of stochastic wind and load on the unit commitment and dispatch of power systems with high levels of wind power are examined. By comparing the costs, planned operation and performance of the schedules produced, it is shown that stochastic optimization results in less costly, of the order of 0.25%, and better performing schedules than deterministic optimization. The impact of planning the system more frequently to account for updated wind and load forecasts is then examined. More frequent planning means more up to date forecasts are used, which reduces the need for reserve and increases performance of the schedules. It is shown that mid-merit and peaking units and the interconnection are the most affected parts of the system where uncertainty of wind is concerned.
651 citations
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23 Jan 1998TL;DR: The Many Faces of Gender and Organization Different Perspectives on Gender Division of Labour and Sex Typing Masculinities, Femininities and Work Gender and Identity Gender, Organizational Culture and Sexuality Women in Management Women in management II Four Positions Broadening the Agenda Reconstructing Gender and Organisation Studies
Abstract: The Many Faces of Gender and Organization Different Perspectives on Gender Division of Labour and Sex Typing Masculinities, Femininities and Work Gender and Identity Gender, Organizational Culture and Sexuality Women in Management Women in Management II Four Positions Broadening the Agenda Reconstructing Gender and Organization Studies
651 citations
Authors
Showing all 58387 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Karin | 236 | 704 | 226485 |
Matthias Mann | 221 | 887 | 230213 |
Peer Bork | 206 | 697 | 245427 |
Ronald Klein | 194 | 1305 | 149140 |
Kenneth S. Kendler | 177 | 1327 | 142251 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Mika Kivimäki | 166 | 1515 | 141468 |
Jun Wang | 166 | 1093 | 141621 |
Anders Björklund | 165 | 769 | 84268 |
Gerald I. Shulman | 164 | 579 | 109520 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Veikko Salomaa | 162 | 843 | 135046 |
Daniel J. Jacob | 162 | 656 | 76530 |