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Institution

University of Copenhagen

EducationCopenhagen, Denmark
About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Medicine. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.


Papers
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Journal ArticleDOI
TL;DR: Differentiation of the burden and risk of babies born preterm and SGA rather than with low birthweight could guide prevention and management strategies to speed progress towards Millennium Development Goal 4--the reduction of child mortality.

660 citations

Journal ArticleDOI
TL;DR: This Review summarizes recent insights on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp.
Abstract: The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p) ppGpp) are involved in regulating growth and several different stress responses in bacteria. In ...

660 citations

Journal ArticleDOI
TL;DR: This review aims at helping scientists in finding the most appropriate and up-to-date methods to study their biofilms by giving a critical perspective, highlighting the advantages and limitations of several methods.
Abstract: Biofilms are widespread in nature and constitute an important strategy implemented by microorganisms to survive in sometimes harsh environmental conditions. They can be beneficial or have a negative impact particularly when formed in industrial settings or on medical devices. As such, research into the formation and elimination of biofilms is important for many disciplines. Several new methodologies have been recently developed for, or adapted to, biofilm studies that have contributed to deeper knowledge on biofilm physiology, structure and composition. In this review, traditional and cutting-edge methods to study biofilm biomass, viability, structure, composition and physiology are addressed. Moreover, as there is a lack of consensus among the diversity of techniques used to grow and study biofilms. This review intends to remedy this, by giving a critical perspective, highlighting the advantages and limitations of several methods. Accordingly, this review aims at helping scientists in finding the most appropriate and up-to-date methods to study their biofilms.

659 citations

Journal ArticleDOI
TL;DR: This review deals with the prospective, experimental documentation of horizontal gene transfer and its role in real-time, local adaptation, and has focused on plasmids and their function as an accessory and/or adaptive gene pool.
Abstract: This review deals with the prospective, experimental documentation of horizontal gene transfer (HGT) and its role in real-time, local adaptation. We have focused on plasmids and their function as an accessory and/or adaptive gene pool. Studies of the extent of HGT in natural environments have identified certain hot spots, and many of these involve biofilms. Biofilms are uniquely suited for HGT, as they sustain high bacterial density and metabolic activity, even in the harshest environments. Single-cell detection of donor, recipient and transconjugant bacteria in various natural environments, combined with individual-based mathematical models, has provided a new platform for HGT studies.

658 citations

Journal ArticleDOI
TL;DR: The resulting data is assembled into a centralized data resource that contains web-based tools and data-access points for the research community to search and extract data related to samples, genes, promoter activities, transcription factors and enhancers across the FANTOM5 atlas.
Abstract: The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines and tissues using CAGE. Based on manual curation of sample information and development of an ontology for sample classification, we assemble the resulting data into a centralized data resource (http://fantom.gsc.riken.jp/5/). This resource contains web-based tools and data-access points for the research community to search and extract data related to samples, genes, promoter activities, transcription factors and enhancers across the FANTOM5 atlas.

656 citations


Authors

Showing all 58387 results

NameH-indexPapersCitations
Michael Karin236704226485
Matthias Mann221887230213
Peer Bork206697245427
Ronald Klein1941305149140
Kenneth S. Kendler1771327142251
Dorret I. Boomsma1761507136353
Ramachandran S. Vasan1721100138108
Unnur Thorsteinsdottir167444121009
Mika Kivimäki1661515141468
Jun Wang1661093141621
Anders Björklund16576984268
Gerald I. Shulman164579109520
Jaakko Kaprio1631532126320
Veikko Salomaa162843135046
Daniel J. Jacob16265676530
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023370
20221,266
202110,694
20209,956
20199,190
20188,620