Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
Papers published on a yearly basis
Papers
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University of Murcia1, Autonomous University of Madrid2, Ain Shams University3, University of Camerino4, Autonomous University of Barcelona5, University of the Azores6, University of La Laguna7, Hebrew University of Jerusalem8, University of Aleppo9, Free University of Berlin10, University of Lisbon11, University of Catania12, University of Belgrade13, University of Liège14
TL;DR: The names of all mosses published up to the end of August 2011 in the countries of the Mediterranean basin, the Macaronesian Islands and Bulgaria are compiled in an annotated checklist that comprises accepted names and synonyms, and provides explanatory annotations for ambiguous and disputed names.
320 citations
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TL;DR: In ICU patients, β-lactam antibiotic half-life and T > MIC were virtually unpredictable, especially in those patients with normal renal function, and the dosing of antibiotics should be supported by PK concepts, including data derived from studies of the PK of ICu patients and therapeutic drug monitoring.
Abstract: Several reports have shown marked heterogeneity of antibiotic pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes. Therefore, the pharmacodynamic (PD) parameter of the efficacy of β-lactam antibiotics, that is, the time that its concentration is above the bacteria minimal inhibitory concentration (T > MIC), cannot be safely extrapolated from data derived from the PK of healthy volunteers. We performed a full review of published studies addressing the PK of intravenous β-lactam antibiotics given to infected ICU patients. Study selection comprised a comprehensive bibliographic search of the PubMed database and bibliographic references in relevant reviews from January 1966 to December 2010. We selected only English-language articles reporting studies addressing β-lactam antibiotics that had been described in at least five previously published studies. Studies of the PK of patients undergoing renal replacement therapy were excluded. A total of 57 studies addressing six different β-lactam antibiotics (meropenem, imipenem, piperacillin, cefpirome, cefepime and ceftazidime) were selected. Significant PK heterogeneity was noted, with a broad, more than twofold variation both of volume of distribution and of drug clearance (Cl). The correlation of antibiotic Cl with creatinine clearance was usually reported. Consequently, in ICU patients, β-lactam antibiotic half-life and T > MIC were virtually unpredictable, especially in those patients with normal renal function. A better PD profile was usually obtained by prolonged or even continuous infusion. Tissue penetration was also found to be compromised in critically ill patients with septic shock. The PK of β-lactam antibiotics are heterogeneous and largely unpredictable in ICU patients. Consequently, the dosing of antibiotics should be supported by PK concepts, including data derived from studies of the PK of ICU patients and therapeutic drug monitoring.
320 citations
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TL;DR: In this article, the authors generalize the f(R) type gravity models by assuming that the gravitational Lagrangian is given by an arbitrary function of the Ricci scalar R and of the matter Lagrangians L m m m − 1, and derive the equations of motion for test particles, which follow from the covariant divergence of the energy-momentum tensor.
Abstract: We generalize the f(R) type gravity models by assuming that the gravitational Lagrangian is given by an arbitrary function of the Ricci scalar R and of the matter Lagrangian L
m
. We obtain the gravitational field equations in the metric formalism, as well as the equations of motion for test particles, which follow from the covariant divergence of the energy-momentum tensor. The equations of motion for test particles can also be derived from a variational principle in the particular case in which the Lagrangian density of the matter is an arbitrary function of the energy density of the matter only. Generally, the motion is non-geodesic, and it takes place in the presence of an extra force orthogonal to the four-velocity. The Newtonian limit of the equation of motion is also considered, and a procedure for obtaining the energy-momentum tensor of the matter is presented. The gravitational field equations and the equations of motion for a particular model in which the action of the gravitational field has an exponential dependence on the standard general relativistic Hilbert–Einstein Lagrange density are also derived.
319 citations
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TL;DR: In this paper, the authors analyzed the mechanical performance of concrete with recycled aggregates from construction and demolition waste (CDW) from various locations in Portugal and concluded that the use of RA worsens most of the properties tested, especially when fine RA are used.
318 citations
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TL;DR: A significant excess of pairs is observed above the yield expected from neutral meson decays at the CERN SPS, and the resulting mass spectrum is consistent with a dominant contribution from pi+pi- -->rho -->mu+mu- annihilation.
Abstract: We report on a precision measurement of low-mass muon pairs in 158 AGeV indium-indium collisions at the CERN SPS. A significant excess of pairs is observed above the yield expected from neutral meson decays. The unprecedented sample size of 360 000 dimuons and the good mass resolution of about 2% allow us to isolate the excess by subtraction of the decay sources. The shape of the resulting mass spectrum is consistent with a dominant contribution from pi+pi--->rho-->µ+µ- annihilation. The associated space-time averaged rho spectral function shows a strong broadening, but essentially no shift in mass. This may rule out theoretical models linking hadron masses directly to the chiral condensate.
317 citations
Authors
Showing all 19716 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joao Seixas | 153 | 1538 | 115070 |
A. Gomes | 150 | 1862 | 113951 |
Marco Costa | 146 | 1458 | 105096 |
António Amorim | 136 | 1477 | 96519 |
Osamu Jinnouchi | 135 | 885 | 86104 |
P. Verdier | 133 | 1111 | 83862 |
Andy Haas | 132 | 1096 | 87742 |
Wendy Taylor | 131 | 1252 | 89457 |
Steve McMahon | 130 | 878 | 78763 |
Timothy Andeen | 129 | 1069 | 77593 |
Heather Gray | 129 | 966 | 80970 |
Filipe Veloso | 128 | 887 | 75496 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
Isabel Marian Trigger | 128 | 974 | 77594 |