Institution
University of Lisbon
Education•Lisbon, Lisboa, Portugal•
About: University of Lisbon is a education organization based out in Lisbon, Lisboa, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 19122 authors who have published 48503 publications receiving 1102623 citations. The organization is also known as: Universidade de Lisboa & Lisbon University.
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University of Copenhagen1, Stanford University2, University of Texas at San Antonio3, Medical College of Wisconsin4, University of Cincinnati5, Detroit Medical Center6, University of Arizona7, University of Iowa8, University of Kansas9, University of Miami10, Grady Memorial Hospital11, Main Line Health12, University of Pittsburgh13, Veterans Health Administration14, Rochester General Health System15, Washington University in St. Louis16, University of Colorado Denver17, University of Pennsylvania18, University of Texas Medical Branch19, Vanderbilt University20, University of Maryland, Baltimore21, North Shore-LIJ Health System22, LSU Health Sciences Center Shreveport23, Women & Children's Hospital of Buffalo24, NorthShore University HealthSystem25, Cleveland Clinic26, University Medical Center27, Tufts University28, University of Toledo29, University of California, Davis30, Rhode Island Hospital31, University of South Alabama32, McGill University33, Foothills Medical Centre34, Université de Montréal35, Trillium Health Centre36, University of Alberta37, Laval University38, University of Western Ontario39, University of British Columbia40, Innsbruck Medical University41, University of Helsinki42, University of Eastern Finland43, Uppsala University44, University of Paris45, Lille University of Science and Technology46, Centre Hospitalier Universitaire de Nice47, Heidelberg University48, University of Cologne49, Ruhr University Bochum50, Charité51, University of Duisburg-Essen52, Ludwig Maximilian University of Munich53, University of Münster54, University of Genoa55, University of Perugia56, University of Groningen57, Erasmus University Rotterdam58, University of Lausanne59, University of Bern60, University of Zurich61, University of Dundee62, Aberdeen Royal Infirmary63, Nottingham City Hospital64, Western Infirmary65, University of Lisbon66, University of Coimbra67, University of Barcelona68, Autonomous University of Barcelona69, Complutense University of Madrid70, University of Melbourne71, Royal Melbourne Hospital72, Alfred Hospital73, North Shore Hospital74, Christchurch Hospital75, Auckland City Hospital76, Stellenbosch University77
TL;DR: The SPARCL Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate the effect of statin treatment in secondary stroke prevention.
Abstract: Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for patients with cerebrovascular disease and no history of CHD remains
169 citations
TL;DR: Because of the large inter-person variability in microbiome composition, the results underline the importance of studying gut microbial metabolic pathways rather than focusing purely on taxonomy to find therapeutic and diagnostic targets.
Abstract: The human gut is inhabited by a complex and metabolically active microbial ecosystem regulating host health. While many studies have focused on the effect of individual microbial taxa, the metabolic potential of the entire gut microbial ecosystem has been largely under-explored. We characterised the gut microbiome of 1,004 twins via whole shotgun metagenomic sequencing (average 39M reads per sample). We observed greater similarity, across unrelated individuals, for functional metabolic pathways (82%) than for taxonomic composition (43%). We conducted a microbiota-wide association study linking both taxonomic information and microbial metabolic pathways with 673 blood and 713 faecal metabolites (Metabolon, Inc.). Metabolic pathways associated with 34% of blood and 95% of faecal metabolites, with over 18,000 significant associations, while species-level results identified less than 3,000 associations, suggesting that coordinated action of multiple taxa is required to affect the metabolome. Finally, we estimated that the microbiome mediated a crosstalk between 71% of faecal and 15% of blood metabolites, highlighting six key species (unclassified Subdoligranulum spp., Faecalibacterium prausnitzii, Roseburia inulinivorans, Methanobrevibacter smithii, Eubacterium rectale, and Akkermansia muciniphila). Because of the large inter-person variability in microbiome composition, our results underline the importance of studying gut microbial metabolic pathways rather than focusing purely on taxonomy to find therapeutic and diagnostic targets.
169 citations
TL;DR: In this article, the authors use deep and homogeneous Gaia photometry down to G=18 to estimate the distance, age, and interstellar reddening for about 2000 clusters identified with Gaia~DR2 astrometry.
Abstract: The large astrometric and photometric survey performed by the Gaia mission allows for a panoptic view of the Galactic disc and in its stellar cluster population. Hundreds of clusters were only discovered after the latest G data release (DR2) and have yet to be characterised. Here we make use of the deep and homogeneous Gaia photometry down to G=18 to estimate the distance, age, and interstellar reddening for about 2000 clusters identified with Gaia~DR2 astrometry. We use these objects to study the structure and evolution of the Galactic disc. We rely on a set of objects with well-determined parameters in the literature to train an artificial neural network to estimate parameters from the Gaia photometry of cluster members and their mean parallax. We obtain reliable parameters for 1867 clusters. Our new homogeneous catalogue confirms the relative lack of old clusters in the inner disc (with a few notable exceptions). We also quantify and discuss the variation of scale height with cluster age, and detect the Galactic warp in the distribution of old clusters. This work results in a large and homogenous cluster catalogue. However, the present sample is still unable to trace the Outer spiral arm of the Milky Way, which indicates that the outer disc cluster census might still be incomplete.
169 citations
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TL;DR: A review of pH definitions and conventions can be found in this article, where the main conclusions of this review are: (1) pH definition and conventions are highly variable, which leads to highly variable estimates of pH.
169 citations
TL;DR: Upregulation of MRP1/Mrp1 protein levels by UCB might represent an important adaptive mechanism that protects the CNS from UCB toxicity and could explain the varied susceptibility of newborns to bilirubin neurotoxicity and the occurrence of neurological damage at plasma UCB concentrations well below therapeutic guidelines.
169 citations
Authors
Showing all 19716 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joao Seixas | 153 | 1538 | 115070 |
| A. Gomes | 150 | 1862 | 113951 |
| Marco Costa | 146 | 1458 | 105096 |
| António Amorim | 136 | 1477 | 96519 |
| Osamu Jinnouchi | 135 | 885 | 86104 |
| P. Verdier | 133 | 1111 | 83862 |
| Andy Haas | 132 | 1096 | 87742 |
| Wendy Taylor | 131 | 1252 | 89457 |
| Steve McMahon | 130 | 878 | 78763 |
| Timothy Andeen | 129 | 1069 | 77593 |
| Heather Gray | 129 | 966 | 80970 |
| Filipe Veloso | 128 | 887 | 75496 |
| Nuno Filipe Castro | 128 | 960 | 76945 |
| Oliver Stelzer-Chilton | 128 | 1141 | 79154 |
| Isabel Marian Trigger | 128 | 974 | 77594 |