Showing papers by "University of Lisbon published in 2006"

Sequence-Based Species Delimitation for the DNA Taxonomy of Undescribed Insects

Abstract: Cataloging the very large number of undescribed species of insects could be greatly accelerated by automated DNA based approaches, but procedures for large-scale species discovery from sequence data are currently lacking. Here, we use mitochondrial DNA variation to delimit species in a poorly known beetle radiation in the genus Rivacindela from arid Australia. Among 468 individuals sampled from 65 sites and multiple morphologically distinguishable types, sequence variation in three mtDNA genes (cytochrome oxidase subunit 1, cytochrome b, 16S ribosomal RNA) was strongly partitioned between 46 or 47 putative species identified with quantitative methods of species recognition based on fixed unique ("diagnostic") characters. The boundaries between groups were also recognizable from a striking increase in branching rate in clock-constrained calibrated trees. Models of stochastic lineage growth (Yule models) were combined with coalescence theory to develop a new likelihood method that determines the point of transition from species-level (speciation and extinction) to population-level (coalescence) evolutionary processes. Fitting the location of the switches from speciation to coalescent nodes on the ultrametric tree of Rivacindela produced a transition in branching rate occurring at 0.43 Mya, leading to an estimate of 48 putative species (confidence interval for the threshold ranging from 47 to 51 clusters within 2 logL units). Entities delimited in this way exhibited biological properties of traditionally defined species, showing coherence of geographic ranges, broad congruence with morphologically recognized species, and levels of sequence divergence typical for closely related species of insects. The finding of discontinuous evolutionary groupings that are readily apparent in patterns of sequence variation permits largely automated species delineation from DNA surveys of local communities as a scaffold for taxonomy in this poorly known insect group.

EFNS guidelines on pharmacological treatment of neuropathic pain

Abstract: Neuropathic pain treatment remains unsatisfactory despite a substantial increase in the number of trials. This EFNS Task Force aimed at evaluating the existing evidence about the pharmacological treatment of neuropathic pain. Studies were identified using first the Cochrane Database then Medline. Trials were classified according to the aetiological condition. All class I and II controlled trials (according to EFNS classification of evidence) were assessed, but lower-class studies were considered in conditions that had no top level studies. Only treatments feasible in an outpatient setting were evaluated. Effects on pain symptoms/signs, quality of life and comorbidities were particularly searched for. Most of the randomized controlled trials included patients with postherpetic neuralgia (PHN) and painful polyneuropathies (PPN) mainly caused by diabetes. These trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine (in PHN) and the newer antidepressants venlafaxine and duloxetine (in PPN). A small number of controlled trials were performed in central pain, trigeminal neuralgia, other peripheral neuropathic pain states and multiple-aetiology neuropathic pains. The main peripheral pain conditions respond similarly well to tricyclic antidepressants, gabapentin, and pregabalin, but some conditions, such as HIV-associated polyneuropathy, are more refractory. There are too few studies on central pain, combination therapy, and head-to-head comparison. For future trials, we recommend to assess quality of life and pain symptoms or signs with standardized tools.

ALICE: Physics Performance Report, Volume II

Abstract: ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark–gluon plasma in nucleus–nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries.The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb–Pb collisions (dNch/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus–nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies.The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC.Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate.The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517–1763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators.The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton–proton, proton–nucleus, and nucleus–nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes.

Stochastic dynamics of invasion and fixation.

Abstract: We study evolutionary game dynamics in finite populations. We analyze an evolutionary process, which we call pairwise comparison, for which we adopt the ubiquitous Fermi distribution function from statistical mechanics. The inverse temperature in this process controls the intensity of selection, leading to a unified framework for evolutionary dynamics at all intensities of selection, from random drift to imitation dynamics. We derive a simple closed formula that determines the feasibility of cooperation in finite populations, whenever cooperation is modeled in terms of any symmetric two-person game. In contrast with previous results, the present formula is valid at all intensities of selection and for any initial condition. We investigate the evolutionary dynamics of cooperators in finite populations, and study the interplay between intensity of selection and the remnants of interior fixed points in infinite populations, as a function of a given initial number of cooperators, showing how this interplay strongly affects the approach to fixation of a given trait in finite populations, leading to counterintuitive results at different intensities of selection.

Search for neutral MSSM Higgs bosons at LEP

Abstract: The four LEP collaborations, ALEPH, DELPHI, L3 and OPAL, have searched for the neutral Higgs bosons which are predicted by the Minimal Supersymmetric standard model (MSSM). The data of the four collaborations are statistically combined and examined for their consistency with the background hypothesis and with a possible Higgs boson signal. The combined LEP data show no significant excess of events which would indicate the production of Higgs bosons. The search results are used to set upper bounds on the cross-sections of various Higgs-like event topologies. The results are interpreted within the MSSM in a number of “benchmark” models, including CP-conserving and CP-violating scenarios. These interpretations lead in all cases to large exclusions in the MSSM parameter space. Absolute limits are set on the parameter cosβ and, in some scenarios, on the masses of neutral Higgs bosons.

The Mediterranean climate: An overview of the main characteristics and issues

Abstract: Publisher Summary The Mediterranean Region has many morphologic, geographical, historical, and societal characteristics, which make its climate scientifically interesting. The concept of Mediterranean climate is characterized by mild wet winters and warm to hot, dry summers and occur on the west side of continents between about 30° and 40° latitude. However, the presence of a relatively large mass of water is unique to the actual Mediterranean region. The Mediterranean Sea is a marginal and semi-enclosed sea; it is located on the western side of a large continental area and is surrounded by Europe to the North, Africa to the South, and Asia to the East. The chapter discusses that the climate of the Mediterranean region is to a large extent forced by planetary scale patterns. The time and space behavior of the regional features associated with such large-scale forcing is complex. Orography and land–sea distribution play an important role establishing the climate at basin scale and its teleconnections with global patterns. Different levels of services of readiness to emergencies, technological, and economic resources are likely to result in very different adaptation capabilities to environmental changes and new problems. The different economic situations and demographic trends are likely to produce contrasts and conflicts in a condition of limited available resources and environmental stress.

Cooperation prevails when individuals adjust their social ties.

Abstract: Conventional evolutionary game theory predicts that natural selection favours the selfish and strong even though cooperative interactions thrive at all levels of organization in living systems. Recent investigations demonstrated that a limiting factor for the evolution of cooperative interactions is the way in which they are organized, cooperators becoming evolutionarily competitive whenever individuals are constrained to interact with few others along the edges of networks with low average connectivity. Despite this insight, the conundrum of cooperation remains since recent empirical data shows that real networks exhibit typically high average connectivity and associated single-to-broad–scale heterogeneity. Here, a computational model is constructed in which individuals are able to self-organize both their strategy and their social ties throughout evolution, based exclusively on their self-interest. We show that the entangled evolution of individual strategy and network structure constitutes a key mechanism for the sustainability of cooperation in social networks. For a given average connectivity of the population, there is a critical value for the ratio W between the time scales associated with the evolution of strategy and of structure above which cooperators wipe out defectors. Moreover, the emerging social networks exhibit an overall heterogeneity that accounts very well for the diversity of patterns recently found in acquired data on social networks. Finally, heterogeneity is found to become maximal when W reaches its critical value. These results show that simple topological dynamics reflecting the individual capacity for self-organization of social ties can produce realistic networks of high average connectivity with associated single-to-broad–scale heterogeneity. On the other hand, they show that cooperation cannot evolve as a result of “social viscosity” alone in heterogeneous networks with high average connectivity, requiring the additional mechanism of topological co-evolution to ensure the survival of cooperative behaviour.

An extrasolar planetary system with three Neptune-mass planets

Abstract: Over the past two years, the search for low-mass extrasolar planets has led to the detection of seven so-called ‘hot Neptunes’ or ‘super-Earths’ around Sun-like stars. These planets have masses 5–20 times larger than the Earth and are mainly found on close-in orbits with periods of 2–15 days. Here we report a system of three Neptune-mass planets with periods of 8.67, 31.6 and 197 days, orbiting the nearby star HD 69830. This star was already known to show an infrared excess possibly caused by an asteroid belt within 1 au (the Sun–Earth distance). Simulations show that the system is in a dynamically stable configuration. Theoretical calculations favour a mainly rocky composition for both inner planets, while the outer planet probably has a significant gaseous envelope surrounding its rocky/icy core; the outer planet orbits within the habitable zone of this star. As the techniques used to search for extrasolar planets have been refined, more and more have been discovered (over 170), and they get smaller. In recent years seven ‘hot Neptunes’ or ‘super-Earths’ have been detected. These have masses 5–20 times larger than the Earth and are in close-in orbits (periods of 2–15 days) around Sun-like stars. Now the first multiple system of three Neptune-mass planets has been found, with periods of 8.67, 31.6 and (in the ‘habitable’ zone) 197 days. They are orbiting the nearby star HD 69830. Theoretical calculations favour a mainly rocky composition for both inner planets. The outer planet probably has a significant gaseous envelope surrounding a rocky/icy core: it is the first Neptune-mass object detected inside the habitable zone of a Sun-like star. Simulations show that the system of three Neptune-mass planets is in a dynamically stable configuration, with theoretical calculations favouring a mainly rocky composition for both inner planets, but a significant gaseous envelope surrounding a rocky/icy core for the outer planet.

Cell-penetrating peptides and antimicrobial peptides: how different are they?

Abstract: Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to translocate across biological membranes in a non-disruptive way and to overcome the impermeable nature of the cell membrane. They have been successfully used for drug delivery into mammalian cells; however, there is no consensus about the mechanism of cellular uptake. Both endocytic and non-endocytic pathways are supported by experimental evidence. The observation that some AMPs (antimicrobial peptides) can enter host cells without damaging their cytoplasmic membrane, as well as kill pathogenic agents, has also attracted attention. The capacity to translocate across the cell membrane has been reported for some of these AMPs. Like CPPs, AMPs are short and cationic sequences with a high affinity for membranes. Similarities between CPPs and AMPs prompted us to question if these two classes of peptides really belong to unrelated families. In this Review, a critical comparison of the mechanisms that underlie cellular uptake is undertaken. A reflection and a new perspective about CPPs and AMPs are presented.

Towards the global monitoring of biodiversity change.

Abstract: Governments have set the ambitious target of reducing biodiversity loss by the year 2010. The scientific community now faces the challenge of assessing the progress made towards this target and beyond. Here, we review current monitoring efforts and propose a global biodiversity monitoring network to complement and enhance these efforts. The network would develop a global sampling programme for indicator taxa (we suggest birds and vascular plants) and would integrate regional sampling programmes for taxa that are locally relevant to the monitoring of biodiversity change. The network would also promote the development of comparable maps of global land cover at regular time intervals. The extent and condition of specific habitat types, such as wetlands and coral reefs, would be monitored based on regional programmes. The data would then be integrated with other environmental and socioeconomic indicators to design responses to reduce biodiversity loss.

Public Sector Efficiency: Evidence for New EU Member States and Emerging Markets

Abstract: In this paper we analyse public sector efficiency in the new member states of the European Union compared to that in emerging markets. After a conceptual discussion of expenditure efficiency measurement issues, we compute efficiency scores and rankings by applying a range of measurement techniques. The study finds that expenditure efficiency across new EU member states is rather diverse especially as compared to the group of top performing emerging markets in Asia. Econometric analysis shows that higher income, civil service competence and education levels as well as the security of property rights seem to facilitate the prevention of inefficiencies in the public sector.

On stationary thermo-rheological viscous flows

Abstract: We study the system of equations describing a stationary thermoconvective flow of a non-Newtonian fluid. We assume that the stress tensor S has the form $\displaystyle \mathbf{S}=-P\mathbf{I}+\left( \mu (\theta )+\tau (\theta ){|\mathbf{D(u)}|}^{p(\theta )-2}\right) {\mathbf{D(u)}}, $ where u is the vector velocity, P is the pressure, θ is the temperature and μ ,p and τ are the given coefficients depending on the temperature. D and I are respectively the rate of strain tensor and the unit tensor. We prove the existence of a weak solution under general assumptions and the uniqueness under smallness conditions. Keywords: Non-Newtonian fluids, Nonlinear thermal diffusion equations, Heat and mass transfer Mathematics Subject Classification (2000): 76A05, 76D07, 76E30, 35G15

First measurement of the rho spectral function in high-energy nuclear collisions

Abstract: We report on a precision measurement of low-mass muon pairs in 158 AGeV indium-indium collisions at the CERN SPS. A significant excess of pairs is observed above the yield expected from neutral meson decays. The unprecedented sample size of 360 000 dimuons and the good mass resolution of about 2% allow us to isolate the excess by subtraction of the decay sources. The shape of the resulting mass spectrum is consistent with a dominant contribution from pi+pi--->rho-->µ+µ- annihilation. The associated space-time averaged rho spectral function shows a strong broadening, but essentially no shift in mass. This may rule out theoretical models linking hadron masses directly to the chiral condensate.

Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials

Abstract: Objective To evaluate the clinical benefit of lipid lowering drug treatment in patients with and without diabetes mellitus, for primary and secondary prevention. Design Systematic review and meta-analysis. Data sources Cochrane, Medline, Embase, and reference lists up to April 2004. Study selection Randomised, placebo controlled, double blind trials with a follow-up of at least three years that evaluated lipid lowering drug treatment in patients with and without diabetes mellitus. Data extraction Two independent reviewers extracted data. The primary outcome was major coronary events defined as coronary heart disease death, non-fatal myocardial infarction, or myocardial revascularisation procedures. Results Twelve studies were included. Lipid lowering drug treatment was found to be at least as effective in diabetic patients as in non-diabetic patients. In primary prevention, the risk reduction for major coronary events was 21% (95% confidence interval 11% to 30%; P Conclusions The evidence that lipid lowering drug treatment (especially statins) significantly reduce cardiovascular risk in diabetic and non-diabetic patients is strong and suggests that diabetic patients benefit more, in both primary and secondary prevention. Future research should define the threshold for treatment of these patients and the desired target lipid concentrations, especially for primary prevention.

A correlation between the heavy element content of transiting extrasolar planets and the metallicity of their parent stars

Abstract: Context. Nine extrasolar planets with masses between 110 and 430M⊕ are known to transit their star. The knowledge of their masses and radii allows an estimate of their composition, but uncertainties on equations of state, opacities and possible missing energy sources imply that only inaccurate constraints can be derived when considering each planet separately. Aims. We seek to better understand the composition of transiting extrasolar planets by considering them as an ensemble, and by comparing the obtained planetary properties to that of the parent stars. Methods. We use evolution models and constraints on the stellar ages to derive the mass of heavy elements present in the planets. Possible additional energy sources like tidal dissipation due to an i nclined orbit or to downward kinetic energy transport are considered. Results. We show that the nine transiting planets discovered so far belong to a quite homogeneous ensemble that is characterized by a mass of heavy elements that is a relatively steep function of the s tellar metallicity, from less than 20 earth masses of heavy elements around solar composition stars, to up to∼ 100 M⊕ for three times the solar metallicity (the precise values be ing model-dependant). The correlation is still to be ascertained however. Statistical tests imply a worst-ca se 1/3 probability of a false positive. Conclusions. Together with the observed lack of giant planets in close orbits around metal-poor stars, these results appear to imply t hat heavy elements play a key role in the formation of close-in giant planets. The large masses of heavy elements inferred for planets orbiting metal rich stars was not anticipated by planet formation models and shows the need for alternative theories including migration and subsequent collection of planetesimals.

Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview.

Abstract: Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease. Homocysteine is a branch-point intermediate of methionine metabolism, which can be further metabolised via two alternative pathways: degraded irreversibly through the transsulphuration pathway or remethylated to methionine by the remethylation pathway. Both pathways are B-vitamin-dependent. Plasma homocysteine concentrations are determined by nongenetic and genetic factors. The metabolism of homocysteine, the role of B vitamins and the contribution of nongenetic and genetic determinants of homocysteine concentrations are reviewed. The mechanisms whereby homocysteine causes endothelial damage and vascular disease are not fully understood. Recently, a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern. The involvement of epigenetic mechanisms in the context of homocysteine and atherosclerosis, due to inhibition of transmethylation reactions, is briefly overviewed.

Microgrids - Large Scale Integration of Microgeneration to Low Voltage Grids

Abstract: Microgrids comprise Low Voltage distribution systems with distributed energy sources, such as micro-turbines, fuel cells, PVs, etc., together with storage devices, i.e. flywheels, energy capacitors and batteries, and controllable loads, offering considerable control capabilities over the network operation. These systems are interconnected to the Medium Voltage Distribution network, but they can be also operated isolated from the main grid, in case of faults in the upstream network. From the customer point of view, Microgrids provide both thermal and electricity needs, and in addition enhance local reliability, reduce emissions, improve power quality by supporting voltage and reducing voltage dips, and potentially lower costs of energy supply. This paper outlines selected research findings of the EU funded MICROGRIDS project (Contract ENK-CT-2002-00610). These include: • Development and enhancement of Microsource controllers to support frequency and voltage based on droops. Application of software agents for secondary control. • Development of the Microgrid Central Controller (MGCC). Economic Scheduling functions have been developed and integrated in a software package able to simulate the capabilities of the MGCC to place bids to the market operator under various policies and to evaluate the resulting environmental benefits. • Analysis of the communication requirements of the Microgrids control architecture • Investigation of alternative market designs for trading energy and ancillary services within a Microgrid. Development of methods for the quantification of reliability and loss reduction. • Initial measurements from an actual LV installation.

Inclusive education ten years after Salamanca: Setting the agenda

Abstract: The articles in this special edition focus on what is, arguably, the biggest challenge facing school systems throughout the world, that of educational inclusion. In economically poorer countries this is mainly about the millions of children who are not able to attend formal education of any kind (Bellamy, 1999). Meanwhile, in wealthier countries many young people leave school with no worthwhile qualifications, whilst others are placed in various forms of special provision away from mainstream educational experiences, and some simply choose to drop out since the lessons seem irrelevant to their lives (Ainscow, 2005; Cesar & Oliveira, 2005). Faced with these challenges, there is evidence of an increased interest in the idea of inclusive education. However, the field remains confused as to what actions need to be taken in order to move policy and practice forward. In some countries, inclusive education is thought of as an approach to serving children with disabilities within general education settings. Internationally, however, it is increasingly seen more broadly as a reform that supports and welcomes diversity amongst all learners (UNESCO, 2001). It presumes that the aim of inclusive education is to eliminate social exclusion that is a consequence of attitudes and responses to diversity in race, social class, ethnicity, religion, gender and ability (Vitello & Mithaug, 1998). As such, it starts from the belief that education is a basic human right and the foundation for a more just society. Just over ten years ago the Salamanca World Conference on Special Needs Education endorsed the idea of inclusive education (UNESCO, 1994). Arguably the most significant international document that has ever appeared in the field of special education, the Salamanca Statement argues that regular schools with an inclusive orientation are "the most effective means of combating discriminatory attitudes, building an inclusive society and achieving education for all" (p. iv). Furthermore, it suggests that such schools can "provide an effective education for the majority of children and improve the efficiency and ultimately the cost effectiveness of the entire education system" (UNESCO, 1994, p. iv). During the subsequent years, there have been considerable efforts in many countries to move educational policy and practice in a more inclusive direction (Freire & Cesar, 2002; Mittler, 2000). In the articles in this special edition, authors from a range of countries present

Discovery of a magma chamber and faults beneath a Mid-Atlantic Ridge hydrothermal field

Abstract: Crust at slow-spreading ridges is formed by a combination of magmatic and tectonic processes, with magmatic accretion possibly involving short-lived crustal magma chambers The reflections of seismic waves from crustal magma chambers have been observed beneath intermediate and fast-spreading centres, but it has been difficult to image such magma chambers beneath slow-spreading centres, owing to rough seafloor topography and associated seafloor scattering In the absence of any images of magma chambers or of subsurface near-axis faults, it has been difficult to characterize the interplay of magmatic and tectonic processes in crustal accretion and hydrothermal circulation at slow-spreading ridges Here we report the presence of a crustal magma chamber beneath the slow-spreading Lucky Strike segment of the Mid-Atlantic Ridge The reflection from the top of the magma chamber, centred beneath the Lucky Strike volcano and hydrothermal field, is approximately 3 km beneath the sea floor, 3-4 km wide and extends up to 7 km along-axis We suggest that this magma chamber provides the heat for the active hydrothermal vent field above it We also observe axial valley bounding faults that seem to penetrate down to the magma chamber depth as well as a set of inward-dipping faults cutting through the volcanic edifice, suggesting continuous interactions between tectonic and magmatic processes

Minimal clinically important change on the unified Parkinson's disease rating scale.

Abstract: The Unified Parkinson's Disease Rating Scale (UPDRS) is the main outcome measure in clinical trials of Parkinson's disease (PD). The minimal change that represents a clinically meaningful improvement is unknown. The objective of this study was to determine the minimal change on the UPDRS that represents a clinically meaningful improvement in early PD after 6 months of treatment. Data from two independent randomized treatment trials over 6 months involving 603 patients with de novo PD were analyzed to determine the minimal clinically important change (MCIC), referred to the status before treatment, for the UPDRS motor, activities of daily living (ADL), and total scores. An anchor-based method using ratings on a seven-point global clinical improvement was used. A change of five points on the UPDRS motor part was found to be the most appropriate cutoff score for all Hoehn and Yahr stages I to III, and a change of eight points for the UDPRS total score. For the UDPRS ADL score, an MCIC of two points for Hoehn and Yahr stages I/I.5 and II and of three points for Hoehn and Yahr stage II.5/III was the most appropriate cutoff score. These data give the first estimate for cutoffs defining clinically important changes in UPDRS ADL and motor scores. Further studies using larger databases from more diverse study populations are encouraged to better define and solidify the MCIC for the UPDRS.

A continental scale evaluation of the role of limpet grazing on rocky shores

Abstract: It is critical for our knowledge of biodiversity and ecosystem processes to understand how individual species contribute to ecosystem processes and how these contributions vary in space and time. We used a manipulative field experiment in five locations over 17° of latitude [from southern Portugal to the Isle of Man (British Isles)] to determine the relative response of rocky intertidal algal assemblages released from control by the grazing of limpets. Response ratios showed that when limpets were removed there was a trend of effects from north to south. In the north, grazing had a strong effect on algal assemblages, but removing grazers reduced spatial variability in assemblages. In the south, the effect of limpet grazing was far weaker and removal of grazers had a much reduced impact on spatial variability. Here we show a clear trophic control of an ecosystem in that grazing by limpets not only determines macroalgal abundance overall but also modifies ecosystem stability via variability in cover of algae.

Supersymmetry parameter analysis : SPA convention and project

Abstract: High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e(+)e(-) linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.

Modeling biodiversity dynamics in countryside landscapes.

Abstract: The future of biodiversity hinges to a great extent on the conservation value of countryside, the growing fraction of Earth's surface heavily influenced by human activities. How many species, and which species, can persist in such landscapes (and analogous seascapes) are open questions. Here we explore two complementary theoretical frameworks to address these questions: species-area relationships and demographic models. We use the terrestrial mammal fauna of Central America to illustrate the application of both frameworks. We begin by proposing a multi-habitat species-area relationship, the countryside species-area relationship, to forecast species extinction rates. To apply it, we classify the mammal fauna by affinity to native and human-dominated habitats. We show how considering the conservation value of countryside habitats changes estimates derived from the classic species-area approach We also examine how the z value of the species-area relationship affects extinction estimates. Next, we present a framework for assessing the relative vulnerability of species to extinction in the countryside, based on the Skellam model of population dynamics. This model predicts the minimum area of contiguous native habitat required for persistence of a species, which we use as an indicator of vulnerability to habitat change. To apply the model, we use our habitat affinity classification of mammals and we estimate life-history parameters by species and habitat type. The resulting ranking of vulnerabilities is significantly correlated with the World Conservation Union (IUCN) Red List assessment.

Neurobehavioral Effects of Dental Amalgam in Children: A Randomized Clinical Trial.

Abstract: ContextDental (silver) amalgam is a widely used restorative material containing 50% elemental mercury that emits small amounts of mercury vapor. No randomized clinical trials have determined whether there are significant health risks associated with this low-level mercury exposure.ObjectiveTo assess the safety of dental amalgam restorations in children.DesignA randomized clinical trial in which children requiring dental restorative treatment were randomized to either amalgam for posterior restorations or resin composite instead of amalgam. Enrollment commenced February 1997, with annual follow-up for 7 years concluding in July 2005.Setting and ParticipantsA total of 507 children in Lisbon, Portugal, aged 8 to 10 years with at least 1 carious lesion on a permanent tooth, no previous exposure to amalgam, urinary mercury level <10 μg/L, blood lead level <15 μg/dL, Comprehensive Test of Nonverbal Intelligence IQ ≥67, and with no interfering health conditions.InterventionRoutine, standard-of-care dental treatment, with one group receiving amalgam restorations for posterior lesions (n = 253) and the other group receiving resin composite restorations instead of amalgam (n = 254).Main Outcome MeasuresNeurobehavioral assessments of memory, attention/concentration, and motor/visuomotor domains, as well as nerve conduction velocities.ResultsDuring the 7-year trial period, children had a mean of 18.7 tooth surfaces (median, 16) restored in the amalgam group and 21.3 (median, 18) restored in the composite group. Baseline mean creatinine-adjusted urinary mercury levels were 1.8 μg/g in the amalgam group and 1.9 μg/g in the composite group, but during follow-up were 1.0 to 1.5 μg/g higher in the amalgam group than in the composite group (P<.001). There were no statistically significant differences in measures of memory, attention, visuomotor function, or nerve conduction velocities (average z scores were very similar, near zero) for the amalgam and composite groups over all 7 years of follow-up, with no statistically significant differences observed at any time point (P values from .29 to .91). Starting at 5 years after initial treatment, the need for additional restorative treatment was approximately 50% higher in the composite group.ConclusionsIn this study, children who received dental restorative treatment with amalgam did not, on average, have statistically significant differences in neurobehavioral assessments or in nerve conduction velocity when compared with children who received resin composite materials without amalgam. These findings, combined with the trend of higher treatment need later among those receiving composite, suggest that amalgam should remain a viable dental restorative option for children.Trial Registrationclinicaltrials.gov Identifier: NCT00066118

Influence of the semiconductor thickness on the electrical properties of transparent TFTs based on indium zinc oxide

Abstract: Multicomponent amorphous oxides are starting to emerge as a class of appealing semiconductor materials for application in transparent electronics. In this work, a high performance bottom-gate n-type transparent thin-film transistors are reported, being the discussion primarily focused on the influence of the indium zinc oxide active layer thickness on the properties of the devices. For this purpose, transparent transistors with active layer thicknesses ranging from 15 nm to 60 nm were produced at room temperature using rf magnetron sputtering. Optical transmittance data in the visible range reveals average transmittance higher than 80%, including the glass substrate. The devices work in the enhancement mode and exhibit excellent saturation drain currents. On–off ratios above 107 are achieved, but this value tends to be lower for devices with thicker semiconductor films, as a result of the decrease in the resistance of the channel region with increasing thickness. Channel mobilities are also quite respectable, with some devices presenting values around 40 cm2/V s, even without any annealing or other post-deposition improvement processes. Concerning the evolution of threshold voltage with the thickness, this work shows that it increases from about 3 V in thicker films up to about 10 V in the thinnest ones. The interesting electrical properties obtained and the versatility arising from the fact that it is possible to modify them changing only the thickness of the semiconductor makes this new transparent transistors quite promising for future transparent ICs.