University of Macau

About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Computer science & Population. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.

Medicinal compounds with antiepileptic/anticonvulsant activities.

Abstract: Summary Objective Epilepsy is a serious neural disease that affects around 50 million people all over the world. Although for the majority patients with epilepsy, seizures are well controlled by currently available antiepileptic drugs (AEDs), there are still >30% of patients suffered from medically refractory epilepsy and approximately 30–40% of all epileptic patients affected by numerous side effects and seizure resistance to the current AEDs. Therefore, many researchers try to develop novel approaches to treat epilepsy, for example, to discover new antiepileptic constituents from herbal medicines. Although there are already several reviews on phytotherapy in epilepsy, most of them placed emphasis on the plant crude extracts or their isolated fractions, not pure active compounds derived from herbal medicines. This article aims to review components in herbal medicines that have shown antiepileptic or anticonvulsant properties. Methods We searched online databases and identified articles using the preset searching syntax and inclusion criteria. The active medicinal compounds that have shown anticonvulsant or antiepileptic activity were included and classified according to structural types. Results We have reviewed herein the active constituents including alkaloids, flavonoids, terpenoids, saponins, and coumarins. The screening models, the seizures-inducing factors and response, the effective dose, the potential mechanisms, as well as the structure-activity relationships in some of these active components have also been discussed. Significance The in vitro and in vivo experimental data reviewed in this paper would supply the basic science evidence for research and development of novel AEDs from medicinal plants.

Do Different Guanxi Types Affect Capability Building Differently? A Contingency View

Abstract: Drawing on social capital theory, this study explores how two types of guanxi – with business partners and with government officials – affect corporate capabilities differently, and examines their contingent value. The results from a survey of 409 firms in China indicate that the two guanxi types differ in the extent to which they contribute to corporate resource-bridging and adaptive capabilities. Specifically, guanxi with government officials is positively associated with resource-bridging capability but not with adaptive capability,whereas guanxi with business partners contributes to both resource-bridging capability and adaptive capability. We also find that technological turbulence weakens the impact of guanxi with government officials on capability building, but strengthens the effect of guanxi with business partners on the establishment of corporate capabilities. In addition, the two types of guanxi are mutually reinforcing in their impacts on respective capability building.

Two-Dimensional Janus Transition Metal Oxides and Chalcogenides: Multifunctional Properties for Photocatalysts, Electronics, and Energy Conversion

Abstract: The fast development of high-performance devices for diverse applications requires nanoscale materials with multifunctional properties, motivating theoretical exploration into novel two-dimensional (2D) materials In this work, we propose a new family of 2D nanomaterials, Janus transition metal oxides and chalcogenides MXY (M = Ti, Zr, or Hf; X = S or Se; Y = O or S; X ≠ Y) monolayers, for their versatile applications We find that the Janus MXY monolayers are semiconductors with a wide range of band gaps ranging from 0739 to 2884 eV We show that TiSO, ZrSO, and HfSO monolayers are promising candidates for photocatalysis because of their suitable band gaps and optimal redox potentials for water splitting, and ZrSeS and HfSeS monolayers are suitable candidates for nanoscale electronics because of their high carrier mobility We further show that TiSO, ZrSO, and ZrSeO monolayers possess large piezoelectric properties because of the broken inversion symmetry stemmed from the different atomic sizes and ele