University of Macau

About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Computer science & Population. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.

A General Robust Linear Transceiver Design for Multi-Hop Amplify-and-Forward MIMO Relaying Systems

Abstract: In this paper, linear transceiver design for multi-hop amplify-and-forward (AF) multi-input multi-output (MIMO) relaying systems with Gaussian distributed channel estimation errors is investigated. Commonly used transceiver design criteria including weighted mean-square-error (MSE) minimization, capacity maximization, worst-MSE/MAX-MSE minimization and weighted sum-rate maximization, are considered and unified into a single matrix-variate optimization problem. A general robust design algorithm is proposed to solve the unified problem. Specifically, by exploiting majorization theory and properties of matrix-variate functions, the optimal structure of the robust transceiver is derived when either the covariance matrix of channel estimation errors seen from the transmitter side or the corresponding covariance matrix seen from the receiver side is proportional to an identity matrix. Based on the optimal structure, the original transceiver design problems are reduced to much simpler problems with only scalar variables whose solutions are readily obtained by an iterative water-filling algorithm. A number of existing transceiver design algorithms are found to be special cases of the proposed solution. The differences between our work and the existing related work are also discussed in detail. The performance advantages of the proposed robust designs are demonstrated by simulation results.

Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish

Abstract: Flavonoids have been reported to be potent antioxidants and beneficial in the treatment of oxidative stress-related diseases. Quercetin, a major flavonoid naturally occurring in plants, deserves attention because of its beneficial effects observed in various in vitro and in vivo neural damage models; however, the actions of quercetin are paradoxical. In an effort to confirm the neuroprotective effect of quercetin and to elucidate its mechanism of action, the neuroprotective effects of quercetin in PC12 cells and in zebrafish models were investigated. In this study, the selective dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA), was used to induce neural damage in PC12 cells and zebrafish models. Pretreatment with quercetin offered neuroprotection against 6-OHDA-induced PC12 cell death. Moreover, quercetin could prevent 6-OHDA-induced PC12 cell apoptosis and 6-OHDA-stimulated dopaminergic neuron loss in zebrafish. Interestingly, quercetin was able to protect, but not rescue the dopaminergic neuron damage when zebrafish were treated with quercetin at different maturation stages of the blood brain barrier. A mechanistic study showed that quercetin could inhibit NO over-production and iNOS over-expression in PC12 cells and could down-regulate the over-expression of pro-inflammatory genes (e.g. IL-1s, TNF-α and COX-2) in zebrafish, suggesting that these genes play a role in the neuroprotective effect of quercetin. The objective of this study was to provide a scientific rationale for the clinical use of quercetin, leading to its development as an effective therapeutic agent for the treatment of Parkinson's disease.

Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine

Abstract: The fresh or dried stems of many Dendrobium species are well known as one of the most expensive tonics in traditional Chinese medicine Documented as a “superior grade” herbal medicine in the ancient text “Shen Nong’s Herbal Classic”, Dendrobium has been used for thousands of years and is now a popular health food worldwide The main chemical components of Dendrobium are alkaloids, aromatic compounds, sesquiterpenoids and polysaccharides, with multiple biological activities, including immunomodulatory, neuroprotective and anti-tumor effects, etc Various qualitative and quantitative methods have been developed for the quality evaluation of Dendrobium In this review, the research progress since the 1930s relating to the chemistry, bioactivity and quality control of Dendrobium is summarized, existing problems and prospects are also discussed