University of Macau

About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Computer science & Population. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.

Synthesis and Bioactivity of Guanidinium-Functionalized Pillar[5]arene as a Biofilm Disruptor

Abstract: Due to the inherent resistance of bacterial biofilms to antibiotics and their serious threat to global public health, novel therapeutic agents and strategies to tackle biofilms are urgently needed. To this end, we designed and synthesized a novel guanidinium-functionalized pillar[5]arene (GP5) that exhibited high antibacterial potency against Gram-negative E. coli (BH101) and Gram-positive S. aureus (ATCC25904) strains. More importantly, GP5 effectively disrupted preformed E. coli biofilms by efficient penetration through biofilm barriers and subsequent destruction of biofilm-enclosed bacteria. Furthermore, host-guest complexation between GP5 and cefazolin sodium, a conventional antibiotic that otherwise shows negligible activity against biofilms, exhibited much enhanced, synergistic disruption activity against E. coli biofilms, thus providing a novel supramolecular platform to effectively disrupt biofilms.

Hybrid Power Quality Compensator With Minimum DC Operation Voltage Design for High-Speed Traction Power Systems

Abstract: A hybrid power quality compensator (HPQC) is proposed in this paper for comprehensive compensation under minimum dc operation voltage in high-speed traction power supplies. Reduction in HPQC operation voltage can lead to a decrease in the compensation device capacity, power consumptions, and installation cost. The parameter design procedures for minimum dc voltage operation of HPQC are being explored. It is shown through simulation results that similar compensation performances can be provided by the proposed HPQC with reduced dc-link voltage level compared to the conventional railway power compensator. The system rating can thus be reduced. It is also verified that HPQC would operate at the minimum dc voltage with the proposed parameter design via simulations. A hardware prototype is constructed and the experimental results show that through the proposed design, HPQC is able to provide system unbalance, reactive power, and harmonic compensation in cophase traction power with reduced operation voltage. The cophase traction power supply with proposed HPQC is suitable for high-speed traction applications.