University of Macau

About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Computer science & Population. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.

Abstract: RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malignancies. Let-7, one of the most well-known tumor suppressors, is frequently down-regulated in a variety of human cancers. The RBP LIN28A/LIN28B, a direct target of the let-7 family of miRNAs, is an inhibitor of let-7 biogenesis and is frequently up-regulated in cancers. Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors is reportedly involved in cancer development, contributing to cellular proliferation, cell death resistance, angiogenesis, metastasis, metabolism reprogramming, tumor-associated inflammation, genome instability, acquiring immortality and evading immune destruction. In this review, we summarized the mechanisms of LIN28A/LIN28B and let-7 loop aberrant regulation in human cancer and discussed the roles and potential mechanisms of the LIN28A/LIN28B and let-7 loop in regulating the hallmarks of cancer. The crosstalk between LIN28A/LIN28B and let-7 loop and certain oncogenes (such as MYC, RAS, PI3K/AKT, NF-κB and β-catenin) in regulating hallmarks of cancer has also been discussed.

High-Performance Hybrid Supercapacitor with 3D Hierarchical Porous Flower-like Layered Double Hydroxide Grown on Nickel Foam As Binder-Free Electrode

Abstract: The synthesis of layered double hydroxide (LDH) as electroactive material has been well reported; however, fabricating an LDH electrode with excellent electrochemical performance at high current density remains a challenge. In this paper, we report a 3D hierarchical porous flower-like NiAl-LDH grown on nickel foam (NF) through a liquid-phase deposition method as a high-performance binder-free electrode for energy storage. With large ion-accessible surface area as well as efficient electron and ion transport pathways, the prepared LDH-NF electrode achieves high specific capacity (1250 C g−1 at 2 A g−1 and 401 C g−1 at 50 A g−1) after 5000 cycles of activation at 20 A g−1 and high cycling stability (76.7% retention after another 5000 cycles at 50 A g−1), which is higher than those of most previously reported NiAl-LDH-based materials. Moreover, a hybrid supercapacitor with LDH-NF as the positive electrode and porous graphene nanosheet coated on NF (GNS-NF) as the negative electrode, delivers high energy density (30.2 Wh kg−1 at a power density of 800 W kg−1) and long cycle life, which outperforms the other devices reported in the literature. This study shows that the prepared LDH-NF electrode offers great potential in energy storage device applications.

A Differential-Fed Microstrip Patch Antenna With Bandwidth Enhancement Under Operation of TM 10 and TM 30 Modes

Abstract: A differential-fed microstrip patch antenna (MPA) with bandwidth enhancement is proposed under the operation of TM10 and TM30 resonant modes in a single patch resonator. Initially, a rectangular differential-fed MPA is theoretically investigated so as to demonstrate that all of the undesired modes between the TM10 and TM30 modes are suppressed or removed out effectively. Then, by symmetrically introducing two pairs of shorting pins, the resonant frequency of TM10 mode is progressively turned up. After that, with the help of two long slots, the resonant frequency of TM30 mode is decreased with slight effect on that of TM10 mode. Furthermore, a short slot is inserted at the center of the patch to cancel the parasitic inductances of the shorting pins and probe feeds. With this arrangement, these two radiative resonant modes are moved in proximity to each other for wideband antenna. Finally, the proposed differential-fed MPA is fabricated and measured. Experimental results illustrate that the impedance bandwidth ( $\vert S_{{{\text {dd}11}}}\vert dB) of the antenna has gained a tremendous increment up to about 13% (1.88–2.14 GHz), while keeping a low profile property with the height of 0.029 free-space wavelength. Additionally, the antenna has achieved a stable gain varied from 5.8 to 7 dBi over the operating band.

Sine Chaotification Model for Enhancing Chaos and Its Hardware Implementation

Abstract: When chaotic systems are used in different practical applications, such as nonlinear control and cryptography, their complex chaos dynamics are strongly required. However, many existing chaotic systems have simple complexity, and this brings negative effects to chaos-based applications. To address this issue, this paper introduces a sine chaotification model (SCM) as a general framework to enhance the chaos complexity of existing one-dimensional (1-D) chaotic maps. The SCM uses a sine function as a nonlinear chaotification transform and applies it to the output of a 1-D chaotic map. The resulting enhanced chaotic map of the SCM has better chaos complexity and a much larger chaotic range than the seed map. Theoretical analysis verifies the efficiency of the SCM. To show the performance of the SCM, we apply SCM to three existing chaotic maps and analyze the dynamics properties of the obtained enhanced chaotic maps. Performance evaluations prove that the three enhanced chaotic maps have more complicated dynamics behaviors than their seed chaotic maps. To show the implementation simplicity of the SCM, we implement the three enhanced chaotic maps using the field-programmable gate array. To investigate the SCM in practical application, we design pseudorandom number generators using the enhanced chaotic maps.

Responsible Gambling: General Principles and Minimal Requirements

Abstract: Many international jurisdictions have introduced responsible gambling programs. These programs intend to minimize negative consequences of excessive gambling, but vary considerably in their aims, focus, and content. Many responsible gambling programs lack a conceptual framework and, in the absence of empirical data, their components are based only on general considerations and impressions. This paper outlines the consensus viewpoint of an international group of researchers suggesting fundamental responsible gambling principles, roles of key stakeholders, and minimal requirements that stakeholders can use to frame and inform responsible gambling programs across jurisdictions. Such a framework does not purport to offer value statements regarding the legal status of gambling or its expansion. Rather, it proposes gambling-related initiatives aimed at government, industry, and individuals to promote responsible gambling and consumer protection. This paper argues that there is a set of basic principles and minimal requirements that should form the basis for every responsible gambling program.