University of Memphis

About: University of Memphis is a education organization based out in Memphis, Tennessee, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 7710 authors who have published 20082 publications receiving 611618 citations. The organization is also known as: U of M.

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Abstract: Exploring and understanding biological and pathological changes are of great significance for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have experienced major progress in this field. Particularly, an emergence of various functional optical nanoprobes has provided enhanced sensitivity, specificity, targeting ability, as well as multiplexing and multimodal capabilities due to improvements in their intrinsic physicochemical and optical properties. However, one of the biggest challenges of conventional optical nanoprobes is their absolute intensity-dependent signal readout, which causes inaccurate sensing and imaging results due to the presence of various analyte-independent factors that can cause fluctuations in their absolute signal intensity. Ratiometric measurements provide built-in self-calibration for signal correction, enabling more sensitive and reliable detection. Optimizing nanoprobe designs with ratiometric strategies can surmount many of the limitations encountered by traditional optical nanoprobes. This review first elaborates upon existing optical nanoprobes that exploit ratiometric measurements for improved sensing and imaging, including fluorescence, surface enhanced Raman scattering (SERS), and photoacoustic nanoprobes. Next, a thorough discussion is provided on design strategies for these nanoprobes, and their potential biomedical applications for targeting specific biomolecule populations (e.g. cancer biomarkers and small molecules with physiological relevance), for imaging the tumor microenvironment (e.g. pH, reactive oxygen species, hypoxia, enzyme and metal ions), as well as for intraoperative image guidance of tumor-resection procedures.

Multifactorial determination of skeletal age at death: A method and blind tests of its accuracy

Abstract: Traditional methods of estimating skeletal age at death have relied solely on the pubic symphyseal face or on this indicator combined with others in nonsystematic ways. A multifactorial method is presented that uses a principal components weighting of five indicators (pubic symphyseal face, auricular surface, radiographs of proximal femur, dental wear, and suture closure). This method has been tested by completely blind assessment of age in two samples from the Todd collection carefully screened for accuracy of stated age at death. Results show a marked superiority of the multifactorial method over any single indicator with respect to both bias and accuracy. This represents the first truly blind test of an age-at-death indicator or system, as the test populations were independent of the system(s) being tested, and the age, sex, and ethnogeographic origin of the individuals being assessed (as well as the compositions of the test samples with respect to these variables) were completely unknown until the tests were completed. Implications for paleodemography are discussed.

Strategic leadership and executive innovation influence: an international multi-cluster comparative study

Abstract: This study investigates the relationship of strategic leadership behaviors with executive innovation influence and the moderating effects of top management team (TMT)'s tenure heterogeneity and social culture on that relationship. Using survey data from six countries comprising three social cultures, strategic leadership behaviors were found to have a strong positive relationship with executive influence on both product–market and administrative innovations. In addition, TMT tenure heterogeneity moderated the relationship of strategic leadership behaviors with executive innovation influence for both types of innovation, while social culture moderated that relationship only in the case of administrative innovation. Copyright © 2005 John Wiley & Sons, Ltd.

Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature

Abstract: This article provides a comprehensive review of the research on smoking and body weight. The relationships between smoking and body weight are evaluated in 70 cross-sectional and longitudinal investigations. The mechanisms responsible for differences in body weight are discussed, the weight-related issues that promote smoking behavior are reviewed, methods for reducing postcessation weight gain are summarized, and future research directions are proposed. A proposed working research model for studying the relationship between smoking, energy balance, and weight gain is offered. It is concluded that smoking and body weight relationships are closely related and pose significant challenges for smoking researchers.

Testing and refining the direct and inferential mediation model of reading comprehension

Abstract: A significant proportion of American high school students struggle with reading comprehension Theoretical models of reading comprehension might help researchers understand these difficulties, because they can point to variables that make the largest contributions to comprehension On the basis of an extensive review of the literature, we created a new model of reading comprehension, the direct and inferential mediation (DIME) model The model hypothesizes relationships among background knowledge, inferences, reading comprehension strategies, vocabulary, and word reading and addresses the direct and mediated effects of these 5 predictors on comprehension The authors tested the fit of the model and 3 variations of the model to data from 175 students in 9th grade The DIME model explained 66% of the variance in comprehension Vocabulary and background knowledge made the largest contributions to comprehension, followed by inference, word reading, and strategies Analyses of participants scoring below the 30th percentile on comprehension showed these students to have low scores on all of the measures The authors suggest that vocabulary and background knowledge interventions might be the best way to begin improving the academic reading comprehension of students like those in the sample