University of Rajasthan

About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.

Graphene and Beyond Graphene MoS2: A New Window in Surface-Plasmon-Resonance-Based Fiber Optic Sensing

Abstract: We theoretically propose a surface-plasmon-based fiber optic biosensor in metal/graphene/MoS2 configuration with molybdenum disulfide (MoS2) as a bio recognition layer. The proposed configuration works in the visible region of the electromagnetic spectrum with a very high sensitivity. A comparative theoretical study of the sensors with different metallic layers of gold (Au), copper (Cu), and aluminum (Al) has been performed. The sensor has been found to be the most sensitive in both Cu/graphene/MoS2 and Al/graphene/MoS2 configurations with sensitivity of 6.2 μm/RIU. In both of the configurations the thicknesses of Cu and Al layers is 50 nm and the number of layers of graphene is 16 and 27, respectively, while only a single layer of MoS2 has been used. The sensitivity of the sensor in the Au/graphene/MoS2 configuration is 5.0 μm/RIU with comparatively high depth of resonance.

MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity.

Abstract: Background: Exposure to environmental tobacco smoke (ETS) leads to higher rates of pulmonary diseases and infections in children. To study the biochemical changes that may precede lung diseases, metabolomic effects on fetal and maternal lungs and plasma from rats exposed to ETS were compared to filtered air control animals. Genome- reconstructed metabolic pathways may be used to map and interpret dysregulation in metabolic networks. However, mass spectrometry-based non-targeted metabolomics datasets often comprise many metabolites for which links to enzymatic reactions have not yet been reported. Hence, network visualizations that rely on current biochemical databases are incomplete and also fail to visualize novel, structurally unidentified metabolites. Results: We present a novel approach to integrate biochemical pathway and chemical relationships to map all detected metabolites in network graphs (MetaMapp) using KEGG reactant pair database, Tanimoto chemical and NIST mass spectral similarity scores. In fetal and maternal lungs, and in maternal blood plasma from pregnant rats exposed to environmental tobacco smoke (ETS), 459 unique metabolites comprising 179 structurally identified compounds were detected by gas chromatography time of flight mass spectrometry (GC-TOF MS) and BinBase data processing. MetaMapp graphs in Cytoscape showed much clearer metabolic modularity and complete content visualization compared to conventional biochemical mapping approaches. Cytoscape visualization of differential statistics results using these graphs showed that overall, fetal lung metabolism was more impaired than lungs and blood metabolism in dams. Fetuses from ETS-exposed dams expressed lower lipid and nucleotide levels and higher amounts of energy metabolism intermediates than control animals, indicating lower biosynthetic rates of metabolites for cell division, structural proteins and lipids that are critical for in lung development. Conclusions: MetaMapp graphs efficiently visualizes mass spectrometry based metabolomics datasets as network graphs in Cytoscape, and highlights metabolic alterations that can be associated with higher rate of pulmonary diseases and infections in children prenatally exposed to ETS. The MetaMapp scripts can be accessed at http:// metamapp.fiehnlab.ucdavis.edu.

Effectiveness of yoga therapy in the treatment of migraine without aura: a randomized controlled trial.

Abstract: Background.—Numerous studies have explored the effectiveness of complementary and alternative medicine in the treatment of migraine but there is no documented investigation of the effectiveness of yoga therapy for migraine management. Objectives.—To investigate the effectiveness of holistic approach of yoga therapy for migraine treatment compared to self-care. Design.—A randomized controlled trial. Methods.—Seventy-two patients with migraine without aura were randomly assigned to yoga therapy or self-care group for 3 months. Primary outcomes were headache frequency (headache diary), severity of migraine (0–10 numerical scale) and pain component (McGill pain questionnaire). Secondary outcomes were anxiety and depression (Hospital anxiety depression scale), medication score. Results.—After adjustment for baseline values, the subjects' complaints related to headache intensity (P < .001), frequency (P < .001), pain rating index (P < .001), affective pain rating index (P < .001), total pain rating index (P < .001), anxiety and depression scores (P < .001), symptomatic medication use (P < .001) were significantly lower in the yoga group compared to the self-care group. Conclusion.—The study demonstrated a significant reduction in migraine headache frequency and associated clinical features, in patients treated with yoga over a period of 3 months. Further study of this therapeutic intervention appears to be warranted.