University of Rajasthan

About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.

Synthesis and characterization of coordination compounds of organotin(IV) with nitrogen and sulfur donor ligands

Abstract: The reactions of dimethyltin dichloride with nitrogen and sulfur donor ligands derived by condensation of S-benzyldithiocarbazate with indol-3-carboxylaldehyde, thiophene-2-aldehyde and furfuraldehyde have been investigated in 1:1 and 1:2 molar ratios in anhydrous alcohol. These ligands act as mononegatively charged bidentate species and coordinate to the central tin(IV) atom through the thiosulfur by proton exchange with the azomethine nitrogen. The newly synthesized complexes have been characterized by elemental analysis, conductance measurements and molecular weight determinations. The mode of bonding and the geometry of the complexes have been suggested on the basis of infrared, electronic and 1H, 13C and 119Sn NMR spectroscopy, and probable structures have been assigned to these complexes. A few representative ligands and their tin(IV) complexes have also been screened for their antifungal and antibacterial activities and found to be quite active in this respect. Copyright © 2001 John Wiley & Sons, Ltd.

Melatonin-induced reduction in age-related accumulation of oxidative damage in mice.

Abstract: The ever-increasing understanding of oxygen radical-linked diseases, including the biological process of aging, has stimulated general interest in modulating these biological events Melatonin has been reported to have antioxidant properties in addition to its known hormonal activities However, reports on low-level chronic administration with its anti-aging influence are scanty Hence, the present study was aimed to investigate the influence of low-dose chronic administration (010 mg/kg body weight/day for 3 months) of melatonin against age-induced oxidative stress in mice tissues, namely brain, liver, spleen and kidney Sixteen-month-old mice were supplemented with melatonin (010 mg/kg body weight/day) for three months and then autopsied (at the age of 19 months) for the biochemical estimation of lipid peroxidation, reduced glutathione (GSH), glutathione disulphide (GSSG), glutathione peroxidase (GSH-Px) and serum phosphatase activity Results indicate that age-induced augmentation (compared to 6-8-week-old mice) in the level of lipid peroxidation, GSSG and acid phosphatase is significantly (P < 0001) ameliorated in melatonin-treated mice Age-induced decline in the level of GSH, GSH-Px and alkaline phosphatase activity is inhibited significantly by the long-term administration of melatonin The findings indicate that low-dose chronic administration of melatonin acts as a free radical scavenger and anti-aging agent