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Open AccessJournal ArticleDOI

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana.

Arabidopsis Genome Initiative
- 14 Dec 2000 - 
- Vol. 408, Iss: 6814, pp 796-815
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TLDR
This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement.
Abstract
The flowering plant Arabidopsis thaliana is an important model system for identifying genes and determining their functions. Here we report the analysis of the genomic sequence of Arabidopsis. The sequenced regions cover 115.4 megabases of the 125-megabase genome and extend into centromeric regions. The evolution of Arabidopsis involved a whole-genome duplication, followed by subsequent gene loss and extensive local gene duplications, giving rise to a dynamic genome enriched by lateral gene transfer from a cyanobacterial-like ancestor of the plastid. The genome contains 25,498 genes encoding proteins from 11,000 families, similar to the functional diversity of Drosophila and Caenorhabditis elegans--the other sequenced multicellular eukaryotes. Arabidopsis has many families of new proteins but also lacks several common protein families, indicating that the sets of common proteins have undergone differential expansion and contraction in the three multicellular eukaryotes. This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement.

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Journal ArticleDOI

Coordination of cell proliferation and cell expansion in the control of leaf size in Arabidopsis thaliana.

TL;DR: The results provide a key, novel concept that explains how leaf size is controlled at the organ level, and suggest an organ-wide mechanism that coordinates cell proliferation with cell expansion during leaf development.
Journal ArticleDOI

Evidence that rice and other cereals are ancient aneuploids.

TL;DR: The genome of the monocotyledonous model plant species rice is analyzed and it is shown that a substantial fraction of all rice genes are found in duplicated segments, suggesting that rice is not an ancient polyploid, but an ancient aneuploid that has experienced the duplication of one—or a large part of one)—chromosome in its evolutionary past, ∼70 million years ago.
Journal ArticleDOI

Complete chloroplast DNA sequence of the moss Physcomitrella patens: evidence for the loss and relocation of rpoA from the chloroplast to the nucleus

TL;DR: The complete chloroplast DNA sequence (122 890 bp) of the moss Physcomitrella patens has been determined and the nuclear rpoA gene encoding the alpha subunit of RNA polymerase (RNAP) from P.patens is isolated and characterized, which indicates that chloroplasts RNAP is encoded separately by chlorOPlast and nuclear genomes in the moss.
Journal ArticleDOI

The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis.

TL;DR: It is proposed that comprehensive analysis of the functions of these genes in Arabidopsis will firmly establish serine, cysteine and aspartic proteases as regulators and effectors of a wide range of plant processes.
Journal ArticleDOI

Global organellar proteomics

TL;DR: Recent literature on the global analysis of subcellular organelles is reviewed and how that information is being used to elucidate basic biological processes that range from cellular signaling pathways through protein-protein interactions to differential expression of proteins in response to external stimuli is discussed.
References
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Journal ArticleDOI

Basic Local Alignment Search Tool

TL;DR: A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score.
Journal ArticleDOI

tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.

TL;DR: A program is described, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases.
Journal ArticleDOI

The Complete Genome Sequence of Escherichia coli K-12

TL;DR: The 4,639,221-base pair sequence of Escherichia coli K-12 is presented and reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident.
Journal ArticleDOI

SCOP: a structural classification of proteins database for the investigation of sequences and structures.

TL;DR: This database provides a detailed and comprehensive description of the structural and evolutionary relationships of the proteins of known structure and provides for each entry links to co-ordinates, images of the structure, interactive viewers, sequence data and literature references.
Journal ArticleDOI

The genome sequence of Drosophila melanogaster

Mark Raymond Adams, +194 more
- 24 Mar 2000 - 
TL;DR: The nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome is determined using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map.
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