Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Segmenting luminance-defined texture boundaries
TL;DR: It is demonstrated that a simple model involving a single stage of filtering is inadequate to explain observer performance when segmenting luminance texture boundaries, but performance can be explained when contrast normalization is added to this one-stage model.
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BRED: bioluminescence energy transfer to dye for monitoring ceramide trafficking in cell
Gita Naseri,Christoph Arenz +1 more
TL;DR: In this paper, a spatially unbiased resonance energy transfer system, called BRED, was developed to monitor the trafficking of the signalling lipid ceramide, to the Golgi, which was used to sense the influx of BODIPY-labeled ceramide into the surrounding membrane.
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Adaptation of utility functions to reward distribution in rhesus monkeys
TL;DR: This study investigated the influence of experienced reward distributions on the shape of utility functions inferred from economic choice in rhesus macaque monkeys and found that reinforcement learning provided a strong basis for explaining these adaptations.
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Sphingolipid Metabolism and Molecular Target Drugs for Cancer
Yoshiko Banno,Mariko Seishima +1 more
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Modelling the role of contour integration in visual inference
TL;DR: In this article , a biologically grounded model of contour integration in a task-driven artificial neural network, and trained it using a gradient-descent variant, was used to explore how brain-like contours integration may be optimized for high-level visual objectives as well as its potential roles in perception.
References
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Journal ArticleDOI
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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