Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Daniela Hartmann,Marthe-Susanna Wegner,Ruth Anna Wanger,Nerea Ferreirós,Yannick Schreiber,Jessica Lucks,Susanne Schiffmann,Gerd Geisslinger,Sabine Grösch +8 more
TL;DR: The data indicate that an increase in ceramide production per se is not critical for cell survival, but the equilibrium between long and very long chain ceramides and possibly protein/protein interactions determine the fate of the cell.
Journal ArticleDOI
Value-based attentional capture influences context-dependent decision-making
TL;DR: Behavioral and electrophysiological data suggest that value- based attentional capture and value-based normalization jointly mediate the influence of context on free-choice decision-making.
Journal ArticleDOI
Dopamine Regulates Two Classes of Primate Prefrontal Neurons That Represent Sensory Signals
TL;DR: It is found that DA modulation of prefrontal neurons is not uniform but tailored to specialized neuronal classes, and DA might play an important role in shaping how the PFC initiates appropriate behavior in response to changes in the sensory environment.
Journal ArticleDOI
Correlations in V1 Are Reduced by Stimulation Outside the Receptive Field
TL;DR: The results suggest that normalization signals may be an important mechanism for modulating correlations, and present annular stimuli that encircled—but did not impinge upon—the RFs of the recorded cells, which reduced correlations in the absence of stimulation of the RF.
Journal ArticleDOI
IGFBP-3: a cell fate pivot in cancer and disease.
Michael A. Johnson,Sue M. Firth +1 more
TL;DR: The literature is reviewed on the paradoxical nature of IGFBP-3, its pro-apoptotic and growth-inhibitory actions versus its cytoprotective andgrowth-potentiating properties, and the implications of targeting IGF BP-3 for treatment of disease.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Apoptosis: a link between cancer genetics and chemotherapy.
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Journal ArticleDOI
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Cristina Mammucari,Giulia Milan,Vanina Romanello,Eva Masiero,Ruediger Rudolf,Paola Del Piccolo,Steven J. Burden,Raffaella Di Lisi,Claudia Sandri,Jinghui Zhao,Alfred L. Goldberg,Stefano Schiaffino,Marco Sandri +12 more
TL;DR: FoxO3 controls the two major systems of protein breakdown in skeletal muscle, the ubiquitin-proteasomal and autophagic/lysosomal pathways, independently and is pointed to as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved.
Journal ArticleDOI
Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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