Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Posted ContentDOI
Learning Divisive Normalization in Primary Visual Cortex
Max F. Günthner,Santiago A. Cadena,Santiago A. Cadena,George H. Denfield,Edgar Y. Walker,Andreas S. Tolias,Matthias Bethge,Matthias Bethge,Alexander S. Ecker,Alexander S. Ecker +9 more
TL;DR: It is found that neurons responding strongly to a specific orientation are preferentially normalized by other neurons that are highly active for similar orientations, rather than being normalized by all neurons as it is currently assumed by textbook models.
Posted ContentDOI
A unified circuit model of attention: Neural and behavioral effects
TL;DR: This work provides the first unified mechanistic account of the effects of attention on neural and behavioral responses, and expands this model into an architecture that can perform visual tasks—a convolutional neural network—in order to show that these neural effects can enhance detection performance.
Posted ContentDOI
Feedback from retinal ganglion cells to the inner retina
TL;DR: The principal neurons of the retina participate in a recurrent circuit much as those in other brain areas, not being a mere collector of retinal signals, but are actively involved in visual computations.
Journal ArticleDOI
Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma.
Catarina M. Morais,Pedro P. Cunha,Tânia Melo,Ana M. Cardoso,Pedro Domingues,M. Rosário M. Domingues,Maria C. Pedroso de Lima,Amália S. Jurado +7 more
TL;DR: Identifying GCS as a key molecular target to increase GBM susceptibility to a new generation chemotherapeutic opens windows to the development of innovative strategies to halt GBM recurrence after surgical resection.
Journal ArticleDOI
The role of ceramide and SEW 2871 in the transcription of enzymes involved in amyloid b precursor protein metabolism in an experimental model of Alzheimer's disease.
TL;DR: The role of ceramide and S1P on APP metabolism is investigated and it is indicated that C2-ceramide significantly decreased the viability of the APPwt, APPsw as well as empty vector-transfected PC12 cells.
References
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Journal ArticleDOI
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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