Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
Modeling lateral geniculate nucleus response with contrast gain control. Part 1: formulation.
TL;DR: A class of models for lateral geniculate nucleus (LGN) on-cell behavior that show under and supersaturation, as well as saturation, for sinusoidal grating stimuli with increasing contrast and predict that different SNR regimes will cause a single neuron to show different contrast response curves.
Journal ArticleDOI
Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids
TL;DR: Using an underexplored hydrozirconation-transmetalation reaction and an unusual three-step-one-pot deprotection sequence, several unnatural (2S,3S)-6-hydroxy-(4E)-sphingenine-containing sphingolipids are synthesized, including a fluoresence-labeled derivative suitable for future biological studies.
Book ChapterDOI
Estimating Visual Motion Using an Event-Based Artificial Retina
TL;DR: This work adapts the spatio-temporal filtering scheme as originally suggested by Adelson and Bergen to make it consistent with the input representation generated by the Dynamic Vision Sensor, and incorporates a competitive stage that operates upon the spatial as well as the feature domain.
Journal ArticleDOI
Ceramide synthase 2 knockdown suppresses trophozoite growth, migration, in vitro encystment and excystment of Entamoeba invadens.
José Manuel Jáuregui-Wade,Jorge Cerbón-Solorzano,Ricardo Ávila-García,Jorge-Tonatiuh Ayala-Sumuano,Jesús Valdés +4 more
TL;DR: Interestingly, EinCerS2 was redistributed close to the plasma membrane during encystation, suggesting that the generation of diacylglycerol (DAG) via synthesis of sphingolipids and the activation protein kinase C might participate in the encystment process of E. invadens.
Journal ArticleDOI
“Fix and Click” for Assay of Sphingolipid Signaling in Single Primary Human Intestinal Epithelial Cells
TL;DR: In this article , a fix-and-click approach was used to investigate sphingolipid signaling in both immortalized cell lines and primary human colonic epithelial cells.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Journal ArticleDOI
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Journal ArticleDOI
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Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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