Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase
Michael V. Airola,William J. Allen,Michael J. Pulkoski-Gross,Lina M. Obeid,Lina M. Obeid,Robert C. Rizzo,Yusuf A. Hannun +6 more
TL;DR: The results suggest that nCDase uses a new catalytic strategy for Zn(2+)-dependent amidases, and generates ceramide specificity by sterically excluding sphingolipids with bulky headgroups and specifically recognizing the small hydroxyl head group of ceramide.
Journal ArticleDOI
Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage.
TL;DR: The findings provide molecular insight into the role of ROS signaling in the anticancer mechanism(s) of SNG and may provide the basis for its use as a nontoxic and an effective therapeutic agent in the treatment of prostate cancer.
Journal ArticleDOI
Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer.
Yuting Wang,Sebastian Hinz,Ortrud Uckermann,Pia Hönscheid,Witigo von Schönfels,Greta Burmeister,Alexander Hendricks,Jacobo Miranda Ackerman,Gustavo B. Baretton,Jochen Hampe,Mario Brosch,Clemens Schafmayer,Andrej Shevchenko,Sebastian Zeissig +13 more
TL;DR: It is demonstrated that in contrast to previous reports, CRC shows a largely preserved lipidome composition that resembles that of normal colonic mucosa, challenging the concept of widespread alterations in lipid metabolism in CRC and suggesting changes in the cellular lipid profile that are limited to selected lipids involved in signaling and the scavenging of reactive oxygen species.
Journal ArticleDOI
Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid
TL;DR: Efficient detection of CPE in biological systems is needed to better define its distribution and biological role(s), which might be crucial for the early development of Drosophila melanogaster and in the developmental stages of Trypanosoma brucei.
Journal ArticleDOI
How biological vision succeeds in the physical world.
TL;DR: This article argues that, given the inability of the visual system to access the properties of the world, these conceptual frameworks cannot account for the behavioral success of biological vision, and presents a way to understand the operating principles of visual circuitry without invoking feature detection, representation, or probabilistic inference.
References
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Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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