Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
TL;DR: It is reported that ceramide kinase (Cerk) is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor Recurrence in multiple genetically engineered mouse models for breast cancer.
Journal ArticleDOI
Critical appraisal of the potential use of cannabinoids in cancer management.
TL;DR: Overall, there is still a great deal of conflicting evidence around the future utility of the cannabinoids, natural or synthetic, as therapeutic agents.
Journal ArticleDOI
MALDI-MS Imaging Reveals Asymmetric Spatial Distribution of Lipid Metabolites from Bisphenol S-Induced Nephrotoxicity
TL;DR: An integrated method involving mass spectrometry-based lipidomics and matrix-assisted laser desorption/ionization-MS imaging, and coregistered multimodal three-dimensional (3D)-MSI was developed for the study of nephrotoxicity in mice exposed to 10 and 100 μg bisphenol S (BPS)/kg body weight/day, and implicated that lipids in the renal cortex were more sensitive to BPS exposure.
Journal ArticleDOI
Acid ceramidase is upregulated in AML and represents a novel therapeutic target.
Su Fern Tan,Xin Liu,Todd E. Fox,Brian M. Barth,Arati Sharma,Stephen D. Turner,Andy Awwad,Alden Dewey,Kenichiro Doi,Barbara Spitzer,Mithun Vinod Shah,Samy A.F. Morad,Dhimant Desai,Shantu Amin,Junjia Zhu,Jason Liao,Jong K. Yun,Jong K. Yun,Mark Kester,David F. Claxton,Hong Gang Wang,Myles C. Cabot,Edward H. Schuchman,Ross L. Levine,David J. Feith,Thomas P. Loughran +25 more
TL;DR: It is demonstrated that AC plays a critical role in AML survival through regulation of both sphingolipid levels and Mcl-1, and proposed that AC warrants further exploration as a novel therapeutic target inAML.
Journal ArticleDOI
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover.
Jorge Simón,Alberto Ouro,Lolia Ala-Ibanibo,Natalia Presa,Teresa C. Delgado,María L. Martínez-Chantar +5 more
TL;DR: This work has reviewed existing literature about sphingolipids and the development of NAFLD andNAFLD-derived HCC and highlighted that increased sphingomyelin and ceramide content is observed during steatosis and NASH.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Journal ArticleDOI
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Cristina Mammucari,Giulia Milan,Vanina Romanello,Eva Masiero,Ruediger Rudolf,Paola Del Piccolo,Steven J. Burden,Raffaella Di Lisi,Claudia Sandri,Jinghui Zhao,Alfred L. Goldberg,Stefano Schiaffino,Marco Sandri +12 more
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Journal ArticleDOI
Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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