Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Mechanisms of Arachidonic Acid In Vitro Tumoricidal Impact
Hatem Tallima,Rashika El Ridi +1 more
TL;DR: In this paper , the potential of arachidonic acid (ARA) for cancer prevention and management, experiments were implemented to disclose the mechanisms of its tumoricidal action, and the results showed that ARA and Cer-mediated inhibition of tumor cell viability appeared to be independent of ROS generation or caspase 3/7 activation.
Journal ArticleDOI
Synthesis of new ceramide analogues with allene in the sphingoid backbone
TL;DR: New ceramide analogues with an allene group in the sphingoid backbone were synthesized, which may provide new resources to study their bioactivities and the structure-activity relationship.
Journal ArticleDOI
Calpain: the regulatory point of myocardial ischemia-reperfusion injury
TL;DR: In this paper , the effects of calpain in various programmed cell death (such as apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, and parthanatos) in myocardial ischemia-reperfusion were discussed.
Patent
Synthetic methods and compounds related thereto
Thomas K. Green,Zhipeng Dai +1 more
TL;DR: In this article, the stereoselective and stereospecific synthetic methods are disclosed to produce compounds, such as, for example, γ, δ-unsaturated-β-hydroxyesters and aminated derivatives thereof.
Posted ContentDOI
Priors for natural image statistics inform confidence in perceptual decisions
TL;DR: The authors investigated the use of prior knowledge in subjective confidence in perceptual decisions and found that participants also used natural image priors to inform their confidence judgements and highlighted the influence of environmental priors on confidence.
References
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Journal ArticleDOI
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Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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