Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
Markedly perturbed hematopoiesis in acid ceramidase deficient mice.
Shaalee Dworski,Alexandra Berger,Caren Furlonger,Joshua M. Moreau,Makoto Yoshimitsu,Jessa Trentadue,Bryan Au,Christopher J. Paige,Jeffrey A. Medin +8 more
TL;DR: ACDase is ubiquitous and catalyzes the degradation of ceramide, and has been implicated in many disorders, including cancer, obesity, diabetes, inflammation, and neurodegenerative diseases.
Journal ArticleDOI
Use of Metabolomics as a Complementary Omic Approach to Implement Risk Criteria for First-Degree Relatives of Gastric Cancer Patients.
Giuseppe Corona,Renato Cannizzaro,Gianmaria Miolo,Laura Caggiari,Mariangela De Zorzi,Ombretta Repetto,Agostino Steffan,Valli De Re +7 more
TL;DR: The main purpose of this study was to investigate serum metabolomic profiles to find additional biomarkers that could be integrated with serum PGs and G17 to improve the diagnosis of GC and the selection of first-degree relatives (FDR) at higher risk of GC development.
Journal ArticleDOI
Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products
Ziwen Yuan,Li-Jia Zhong,Yongli Hua,Peng Ji,Wanling Yao,Qi Ma,Xiaosong Zhang,Yanqiao Wen,Lihong Yang,Yanming Wei +9 more
TL;DR: This study provides a reference for understanding the pathological mechanism of BSS and the mechanism of DG PPs, which lays a theoretical foundation for the rational use of DGPPs in clinical practice.
Journal ArticleDOI
Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.
Samy A.F. Morad,Samy A.F. Morad,Traci S. Davis,Matthew R. MacDougall,Su Fern Tan,David J. Feith,Dhimant Desai,Shantu Amin,Mark Kester,Thomas P. Loughran,Myles C. Cabot +10 more
TL;DR: The results suggest that the C6‐ceramide‐containing regimens could provide alternative, promising therapeutic direction, in addition to finding novel, off‐label applications for P‐gp inhibitors, as adjuvants for improving the efficacy of ceramide‐centric therapeutics in treatment of cancer.
Journal ArticleDOI
Dietary Patterns, Ceramide Ratios, and Risk of All-Cause and Cause-Specific Mortality: The Framingham Offspring Study.
Maura E Walker,Vanessa Xanthakis,Linda R. Peterson,Meredith S. Duncan,Meredith S. Duncan,Joowon Lee,Jiantao Ma,Sherman J Bigornia,Lynn L. Moore,Paula A. Quatromoni,Ramachandran S. Vasan,Paul F. Jacques +11 more
TL;DR: In this community-based sample, ceramide ratios were associated with a lower risk of all-cause and cause-specific mortality and that dietary patterns have distinct relations with ceramide ratio.
References
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Journal ArticleDOI
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI
Apoptosis: a link between cancer genetics and chemotherapy.
TL;DR: Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
Journal ArticleDOI
FoxO3 controls autophagy in skeletal muscle in vivo.
Cristina Mammucari,Giulia Milan,Vanina Romanello,Eva Masiero,Ruediger Rudolf,Paola Del Piccolo,Steven J. Burden,Raffaella Di Lisi,Claudia Sandri,Jinghui Zhao,Alfred L. Goldberg,Stefano Schiaffino,Marco Sandri +12 more
TL;DR: FoxO3 controls the two major systems of protein breakdown in skeletal muscle, the ubiquitin-proteasomal and autophagic/lysosomal pathways, independently and is pointed to as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved.
Journal ArticleDOI
Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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