Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer.
TL;DR: How different LTPs as well as MCSs can contribute to cell transformation and malignant phenotype are described, and how “aberrant” M CSs are associated with tumorigenesis in human are discussed.
Journal ArticleDOI
Feature extraction and integration underlying perceptual decision making during courtship behavior.
Jan Clemens,Bernhard Ronacher +1 more
TL;DR: This framework provided a rich and plausible explanation of behavior in terms of two stimulus cues that were extracted by models of sensory neurons and combined through excitatory–inhibitory interactions, and was able to link single neuron's feature selectivity and network computations with decision making in a natural task.
Journal ArticleDOI
Role of sphingomyelinases in neurological disorders
TL;DR: These enzymes, which catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine, are abundant in the brain and a major, rapid source of ceramide production not only during physiological responses to receptor stimulation, but also in neurological disorders.
Journal ArticleDOI
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer
Nicole Sänger,Eugen Ruckhäberle,Balazs Gyorffy,Knut Engels,TM Heinrich,Tanja Fehm,Anna Graf,Uwe Holtrich,Sven Becker,Thomas Karn +9 more
TL;DR: High ASAH1 expression is generally associated with an improved prognosis in invasive breast cancer independent of adjuvant treatment and could also be valuable as prognostic factor for pre‐invasive DCIS.
Journal ArticleDOI
Divisive Gain Modulation of Motoneurons by Inhibition Optimizes Muscular Control
Mikkel Vestergaard,Rune W. Berg +1 more
TL;DR: This work uses turtle hindlimb scratching as a model for fine motor control and finds that not only is the gain of motoneurons regulated on a subsecond timescale, it is also adjusted to minimize variability.
References
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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