Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
More filters
Journal ArticleDOI
Highly-accurate metabolomic detection of early-stage ovarian cancer.
David A. Gaul,Roman Mezencev,Tran Q. Long,Christina M. Jones,Benedict B. Benigno,Alexander G. Gray,Facundo M. Fernández,John F. McDonald +7 more
TL;DR: The results provide evidence for the importance of lipid and fatty acid metabolism in OC and serve as the foundation of a clinically significant diagnostic test.
Journal ArticleDOI
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.
E. Ellen Jones,Shaalee Dworski,Daniel Canals,Josefina Casas,Gemma Fabriàs,Drew Schoenling,Thierry Levade,Chadrick E. Denlinger,Yusuf A. Hannun,Jeffrey A. Medin,Jeffrey A. Medin,Richard R. Drake +11 more
TL;DR: A novel MALDI-FTICR imaging mass spectrometry workflow is described for on-tissue detection, spatial localization, and structural confirmation of low abundance bioactive ceramides and other sphingolipids in tissues.
Journal ArticleDOI
Stimulus Dependence of Correlated Variability across Cortical Areas
Douglas A. Ruff,Marlene R. Cohen +1 more
TL;DR: Recording simultaneously from neurons in two areas of visual cortex while rhesus monkeys viewed different visual stimuli in different attention conditions found that correlations between neurons in different areas depend on stimulus and attention conditions in very different ways than do correlations within an area.
Journal ArticleDOI
Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus.
Daniel J. Denman,Diego Contreras +1 more
TL;DR: Tuning properties suggest wide convergence of Ntsr1 cells with similar spatial and temporal frequency tuning onto single dLGN cells and these nonspecific changes occur independently of changes in burst frequency, indicating that NtsR1 corticogeniculate activity can result in both net excitation and net inhibition.
Journal ArticleDOI
Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide
Jahangir Iqbal,Meghan T. Walsh,Samar M. Hammad,Marina Cuchel,Patrizia Tarugi,Robert A. Hegele,Nicholas O. Davidson,Daniel J. Rader,Richard L. Klein,Richard L. Klein,M. Mahmood Hussain,M. Mahmood Hussain +11 more
TL;DR: The role of microsomal triglyceride transfer protein (MTP), required for B-lp assembly and secretion, in sphingolipid transport to the plasma was investigated and it was found that MTP transferred these lipids between vesicles in vitro.
References
More filters
Journal ArticleDOI
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI
Apoptosis: a link between cancer genetics and chemotherapy.
TL;DR: Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
Journal ArticleDOI
FoxO3 controls autophagy in skeletal muscle in vivo.
Cristina Mammucari,Giulia Milan,Vanina Romanello,Eva Masiero,Ruediger Rudolf,Paola Del Piccolo,Steven J. Burden,Raffaella Di Lisi,Claudia Sandri,Jinghui Zhao,Alfred L. Goldberg,Stefano Schiaffino,Marco Sandri +12 more
TL;DR: FoxO3 controls the two major systems of protein breakdown in skeletal muscle, the ubiquitin-proteasomal and autophagic/lysosomal pathways, independently and is pointed to as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved.
Journal ArticleDOI
Targeting mitochondria for cancer therapy
Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
TL;DR: The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative phosphorylation, in anabolic reactions and activation of the cell death machinery by stimulating mitochondrial membrane permeabilization could therefore be promising therapeutic approaches.
Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
Related Papers (5)
Principles of bioactive lipid signalling: lessons from sphingolipids
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more