Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance
Jorida Coku,David Booth,Jan Skoda,Madison C. Pedrotty,Jennifer Vogel,Kang-Da Liu,Annette Vu,Erica L. Carpenter,J. Ye,Michelle Chen,P. Dunbar,Elizabeth W. Scadden,Taekyung D Yun,Eiko Nakamaru-Ogiso,Estela Area-Gomez,Yi-min Li,Kelly C. Goldsmith,C. Patrick Reynolds,György Hajnóczky,Michael D. Hogarty +19 more
TL;DR: Electron microscopy identifies ER–mitochondria‐associated membranes as physiologic regulators of apoptosis via ceramide transfer and uncover a previously unrecognized mechanism for cancer multidrug resistance.
Journal ArticleDOI
Estimation of PKCδ autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches
Matus Misuth,Jaroslava Joniova,Dominik Belej,Stanislav Hrivnak,Denis Horvath,Veronika Huntosova +5 more
TL;DR: It is suggested, that numerical methods can significantly improve quantification of biomacromolecules (p(S645)PKCδ) directly from the fluorescence images and such obtained outputs are complementary if not equal to typical used methods in biology.
Journal ArticleDOI
Neural plasticity and concepts ontogeny
Alessio Plebe,Marco Mazzone +1 more
TL;DR: The conclusion is that Laurence and Margolis are right in their appeal to innate constraints on connectivity—a thesis that is nowadays welcome to both nativists and non-nativists—but there is little support for their claim of further innate differentiation between and within cortical areas.
Posted ContentDOI
Linguistic structure and meaning organize neural oscillations into a content-specific hierarchy
Greta Kaufeld,Hans R. Bosker,Hans R. Bosker,Phillip M. Alday,Antje S. Meyer,Antje S. Meyer,Andrea E. Martin,Andrea E. Martin +7 more
TL;DR: This paper used EEG data to investigate whether oscillations are modulated by linguistic content over and above the speech stimulus' rhythmicity and temporal distribution, and found that compositional structure and meaning organize the oscillatory response, above and beyond acoustic and lexical controls.
Posted ContentDOI
Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons
TL;DR: In this paper, it was shown that repeated synaptic stimulation results in an activity-dependent decrease in NMDAR activity by vesicular zinc, which shifted the threshold for dendritic nonlinearities and strongly reduced LTP induction.
References
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Cristina Mammucari,Giulia Milan,Vanina Romanello,Eva Masiero,Ruediger Rudolf,Paola Del Piccolo,Steven J. Burden,Raffaella Di Lisi,Claudia Sandri,Jinghui Zhao,Alfred L. Goldberg,Stefano Schiaffino,Marco Sandri +12 more
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Journal ArticleDOI
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Simone Fulda,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Guido Kroemer,Guido Kroemer +6 more
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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