Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing
TL;DR: The yeast surface cDNA display/deep sequencing approach is a rapid, comprehensive, and flexible method for the analysis of protein-ligand interactions, particularly for the study of non-protein ligands.
Journal ArticleDOI
Working Memory Resources Are Shared across Sensory Modalities
TL;DR: The results show thatWorking memory is limited by the precision of the stored representations, and that working memory can be described as a resource pool that is shared across modalities.
Journal ArticleDOI
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer
Sung Won Jang,Woo Jae Park,Hyeonji Min,Taeg Kyu Kwon,Seong Kyu Baek,Ilseon Hwang,Shin Kim,Jong-Wook Park +7 more
TL;DR: Findings indicated that CERS2, CERS4, Cers5, and CERS6 are significantly dysregulated in CRC, suggesting they may serve important roles in the pathophysiology of this malignancy.
Journal ArticleDOI
New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway
TL;DR: A new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells is suggested.
Journal ArticleDOI
LC-MS Based Sphingolipidomic Study on A2780 Human Ovarian Cancer Cell Line and its Taxol-resistant Strain.
Hao Huang,Tian-Tian Tong,Lee-Fong Yau,Cheng-Yu Chen,Jia-Ning Mi,Jing-Rong Wang,Zhi-Hong Jiang +6 more
TL;DR: This is the most comprehensive sphingolipidomic analysis of A 2780 and A2780T, which investigated significantly changed sphingoipid profile in taxol-resistant cancer cells.
References
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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