Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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A mechanistic perspective on canonical neural computation
TL;DR: Paz et al. the authors presented Wajnerman paz, Abel, et al., the authors, which is a paper of the Consejo Nacional de Investigaciones Cientificas y Tecnicas.
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Reduction of Thermotolerance by Heat Shock Protein 90 Inhibitors in Murine Erythroleukemia Cells.
TL;DR: Results suggest that HSP90α in MEL cells plays an important role in the thermotolerance, i.e., suppression of heat stress-induced apoptosis by heat shock.
Proceedings ArticleDOI
FLIM Imaging of NAD(P)H to track metabolic changes of non-adherent leukemia cells using micro cell trapping arrays
Ruofan Cao,Horst Wallrabe,Chunbo Huang,Su Fern Tan,David J. Feith,Yuan Xing,Yong Wang,Jose Oberholzer,Mark Kester,Thomas P. Loughran,Ammasi Periasamy +10 more
TL;DR: A proto-type micro cell trapping array (MCTA) is developed to immobilize cells in picoliter-size wells with location references to isolate treatment responses of a small number of cells, compare their range and predict early effect, which may have clinical applications in the context of cancer aggressiveness and treatment outcomes.
Book ChapterDOI
Spatial Numerosity: A Computational Model Based on a Topological Invariant
Tobias Kluth,Christoph Zetzsche +1 more
TL;DR: A general solution to the estimation of the cardinality of objects in a spatial environment based on concepts and quantities like connectedness and Gaussian curvature is provided and applied to the numerosity estimation from visual stimuli.
Journal ArticleDOI
A Novel Jaspine B ? Ceramide Hybrid Modulates Sphingolipid Metabolism
Virginie Garcia,Pauline Le Faouder,Aude Dupuy,Thierry Levade,Stéphanie Ballereau,Yves Genisson +5 more
TL;DR: This compound was shown to lower the sphingomyelin cellular levels and significantly enhance the production of sphingosine‐1‐phosphate, thus representing a novel sphingolipid metabolism modulator.
References
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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