Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Journal ArticleDOI
The Role of Fatty Acids in Ceramide Pathways and Their Influence on Hypothalamic Regulation of Energy Balance: A Systematic Review.
Andressa Reginato,Andressa Reginato,Andressa Reginato,Alana Carolina Costa Veras,Alana Carolina Costa Veras,Mayara da Nóbrega Baqueiro,Mayara da Nóbrega Baqueiro,Carolina Panzarin,Carolina Panzarin,Beatriz Piatezzi Siqueira,Beatriz Piatezzi Siqueira,Marciane Milanski,Marciane Milanski,Patricia Cristina Lisboa,Adriana Souza Torsoni,Adriana Souza Torsoni +15 more
TL;DR: In this article, the role of sphingolipid levels and their role in hypothalamic energy balance control in obesity was investigated, and it was shown that S1P appears to be a central satiety factor in the hypothalamus, leading to insulin/leptin resistance.
Journal ArticleDOI
Cancer stem cells and ceramide signaling: the cutting edges of immunotherapy
TL;DR: This review focused on the recent findings on broad spectrum of ceramide mediated signaling in CSCs within the tumor niche and their role in potential cancer immunotherapy.
Journal ArticleDOI
Molecular signatures associated with prostate cancer cell line (PC-3) exposure to inactivated Zika virus
Jeany Delafiori,Estela de Oliveira Lima,Mohamed Ziad Dabaja,Flávia Luísa Dias-Audibert,Diogo Noin de Oliveira,Carlos Fernando Odir Rodrigues Melo,Karen Noda Morishita,Geovana Manzan Sales,Ana Lúcia Tasca Gois Ruiz,Gisele Goulart da Silva,Marcelo Lancellotti,Rodrigo Ramos Catharino +11 more
TL;DR: This is the first reported metabolomic assessment of ZIKV effect on prostate cancer cells, and highlights molecular signatures of ZVp-induced response that may be involved on cellular pathways triggered by its antiproliferative effect.
Posted ContentDOI
Inference of Nonlinear Spatial Subunits in Primate Retina with Spike-Triggered Clustering
Nishal P. Shah,Nora Brackbill,Colleen Rhoades,Alexandra Kling,Georges Goetz,Alan Litke,Alexander Sher,Eero P. Simoncelli,Eero P. Simoncelli,E. J. Chichilnisky +9 more
TL;DR: This work presents a novel method for maximum likelihood estimation of nonlinear subunits by soft-clustering spike-triggered stimuli that was more accurately explained by a model with multiple subunits, and was stronger in OFF cells than ON cells.
Journal ArticleDOI
Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells.
Núria Bielsa,Mireia Casasampere,Mazen Aseeri,Josefina Casas,Antonio Delgado,José Luis Abad,Gemma Fabriàs +6 more
TL;DR: In this article, the synthesis and screening of two series of 1-deoxy(dihydro)ceramide analogs on the ACER3 enzymes was reported, and the results showed that the molecules elicited a remarkable AC inhibitory activity in either experimental setup, while using rhNC, several compounds of both series were active as noncompetitive inhibitors with Ki values between 1 and 5μM.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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