Journal ArticleDOI
Ceramide-orchestrated signalling in cancer cells
Samy A.F. Morad,Myles C. Cabot +1 more
TLDR
This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide.Abstract:
One crucial barrier to progress in the treatment of cancer has been the inability to control the balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past 15 years have elevated this sphingolipid to the lofty position of a regulator of cell fate. Ceramide, it turns out, is a powerful tumour suppressor, potentiating signalling events that drive apoptosis, autophagic responses and cell cycle arrest. However, defects in ceramide generation and metabolism in cancer cells contribute to tumour cell survival and resistance to chemotherapy. This Review focuses on ceramide signalling and the targeting of specific metabolic junctures to amplify the tumour suppressive activities of ceramide. The potential of ceramide-based therapeutics in the treatment of cancer is also discussed.read more
Citations
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Instance-level contrastive learning yields human brain-like representation without category-supervision
Talia Konkle,George A. Alvarez +1 more
TL;DR: This paper presents the first evidence to date showing that self-supervised systems can show more brain-like representation than category-super supervised models, and compares the internal representations learned by this model and other instance-level contrastive learning systems to the structure of human brain responses.
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Altered expression of metabolic pathways in CLL detected by unlabelled quantitative mass spectrometry analysis
Lauren A. Thurgood,Eveline S Dwyer,Karen M. Lower,Tim Chataway,Bryone J. Kuss,Bryone J. Kuss +5 more
TL;DR: A novel quantitative proteomic technique applied for the first time to primary patient samples in CLL highlights that primary CLL lymphocytes display markers of a metabolic shift towards lipid synthesis and breakdown, more evident in patients with aggressive disease (UM‐CLL).
Journal ArticleDOI
New Insights into the Connection Between Histone Deacetylases, Cell Metabolism, and Cancer
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Journal ArticleDOI
Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m.
John J. Bassett,Alice H.L. Bong,Ellen K. Janke,Mélanie Robitaille,Sarah J. Roberts-Thomson,Amelia A. Peters,Gregory R. Monteith +6 more
TL;DR: The utility of GCaMP6 Ca2+ indicators for investigating [Ca2+]CYT changes in breast cancer cells during events relevant to tumor progression, which occur over hours rather than minutes is demonstrated.
Journal ArticleDOI
Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs
Peter Kubiniok,Brendan T. Finicle,Fanny Piffaretti,Alison N. McCracken,Michael S. Perryman,Stephen Hanessian,Aimee L. Edinger,Pierre Thibault +7 more
TL;DR: Dynamic phosphoproteomics of cells treated with compounds affecting PP2A activity enabled the correlation of cell signaling with phenotypes to rationalize their mode of action.
References
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Journal ArticleDOI
Biologically active sphingolipids in cancer pathogenesis and treatment.
Besim Ogretmen,Yusuf A. Hannun +1 more
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
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