Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Journal ArticleDOI
Effects of reduced platelet count on the prognosis for patients with non-small cell lung cancer treated with EGFR-TKI: a retrospective study.
TL;DR: The platelet count may predict the prognosis for EGFR-TKI treatment without additional costs and serve as a meaningful parameter to establish the prognostic model for NSCLC patients receiving anti-EGFR targeted therapy.
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The Significance of Platelet–Albumin–Bilirubin (PALBI) Grade in Hepatocellular Carcinoma Patients Stratified According to Platelet Count
Qing Pang,Qing Pang,Shuangchi Liu,Luyao Wang,Huadong Pan,Chunfang Wang,Lei Zhou,Yimin Lu,Huichun Liu +8 more
TL;DR: In this article, the authors investigated the prognostic value of platelet-albumin-bilirubin (PALBI) in HCC patients with thrombocytopenia and excluding thrombinia.
Book ChapterDOI
Hypoxia and the Tumor Secretome.
TL;DR: Current evidence for a hypoxia-induced tumor secretome and its impact on metastatic progression is reviewed and potential biomarkers and therapeutic targets that could be integrated into strategies for preventing and treating metastatic disease are identified.
Journal ArticleDOI
Platelets, Coagulation and Cancer: Multifaceted Interactions
Hadi Goubran,Thierry Burnouf +1 more
TL;DR: The mechanisms through which cancer interacts with platelets and the coagulation, triggering thrombosis and the role played by platelet and coagulated factors in the regulation of cancer are reviewed to underline the perspectives that are now open in the development of novel diagnostic tools and new cancer treatment strategies.
Book ChapterDOI
Systems biology of megakaryocytes.
TL;DR: The molecular pathways that regulate megakaryocyte production have been identified through multiple candidate gene approaches as discussed by the authors, and the best studied pathways are the signal transducers and activators of transcription (STAT) proteins; phosphoinositol-3-kinase; mitogen-activated protein kinases; the phosphatases PTEN, SHP1 and SHP2, and SHIP1; and suppressors of cytokine signaling (SOCS) proteins.
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