Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Journal ArticleDOI
Preoperative platelet-to-lymphocyte ratio is a valuable prognostic biomarker in patients with hepatocellular carcinoma undergoing curative liver resection.
Hao-Jie Yang,Jing-Hang Jiang,Qing-An Liu,Cheng-Mao Zhou,Yang-Feng Du,Tao Wu,Neng-Zhi Chen,Bang-De Xiang +7 more
TL;DR: E Elevated preoperative PLR may be independently associated with poor OS and DFS in HCC patients following curative resection after curative liver resection.
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The phospholipidomic signatures of human blood microparticles, platelets and platelet-derived microparticles: a comparative HILIC-ESI-MS investigation.
Ilario Losito,Elena Conte,Tommaso R. I. Cataldi,Nicola Cioffi,Francesco M. Megli,Francesco Palmisano +5 more
TL;DR: The relative abundance of lyso-phosphatidylcholines among the eight identified phospholipid classes was found to be significantly higher in the lipid extracts of blood microparticles, and a higher relative incidence of species bearing polyunsaturated side chains, was observed in the case of bloodmicroparticles.
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Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin β3 Expression
Yumiko Hayashi,Weizhen Jia,Hiroyasu Kidoya,Fumitaka Muramatsu,Yohei Tsukada,Nobuyuki Takakura +5 more
TL;DR: It is shown that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential, which indicates that changes ofGal-3 expression in cancer cells during tumor progression influence the characteristics of metastatic cells.
Journal ArticleDOI
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules.
TL;DR: In this paper, the authors introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules (CAMs) in it.
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Platelet-lymphocyte ratio is an independent prognostic factor in patients with ALK-positive non-small-cell lung cancer.
Ying Han,Jing Wang,Liping Hong,Leina Sun,Hongqing Zhuang,Bingsheng Sun,Hua Wang,Xinwei Zhang,Xiubao Ren +8 more
TL;DR: PLR is an independent prognostic factor in ALK-positive NSCLC and appears to be associated with survival, according to multivariate analyses.
References
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