Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Combined PLT and NE to predict the prognosis of patients with locally advanced cervical cancer
TL;DR: PLT and NE were correlated with outcomes of the patients with locally advanced cervical cancer and both high levels of pre-radiotherapy PLT and Neutrophils group orHigh levels of post-radIotherapy PLt and NE group were correlation with worst overall survival (OS) compared with the other two groups.
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Dynamic platelet function is markedly different in patients with cancer compared to healthy donors.
Jonathan Cowman,Louis Richter,Roisin Walsh,Niamh M. Keegan,Willard Tinago,Antonio J. Ricco,Bryan T. Hennessy,Dermot Kenny,Eimear Dunne +8 more
TL;DR: It was found that patients with cancer had decreased numbers of platelets interacting, translocating and adhering to VWF and there were also reductions in the speed and distances that platelets traveled on VWF in comparison to healthy controls.
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Comparison of the uptake of untargeted and targeted immunostimulatory nanoparticles by immune cells in the microenvironment of metastatic breast cancer
TL;DR: Using common targeting ligands, the authors developed four nanoparticle variants and assessed their microdistribution in the tumor immune microenvironment in three different breast cancer landscapes, including primary tumor, early and late metastasis.
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Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy.
TL;DR: In this article, the authors summarize current advancements in the functional genomic analysis of breast cancer metastasis and discuss about the potential prognostic and therapeutic implications from the recent genomic findings, which is a complicated and poorly understood process.
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Breast cancer recurrence after reoperation for surgical bleeding.
R. N. Pedersen,Krishnan Bhaskaran,Uffe Heide-Jørgensen,Mette Nørgaard,Peer Christiansen,Niels Kroman,Henrik Toft Sørensen,Deirdre Cronin-Fenton +7 more
TL;DR: This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence and found that it is not associated with recurrence.
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