Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
More filters
Journal ArticleDOI
Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice.
Jose A. Guerrero,Cavan Bennett,Louise van der Weyden,Harriet McKinney,Melody Chin,Paquita Nurden,Zoe McIntyre,Emma L. Cambridge,Jeanne Estabel,Hannah Wardle-Jones,Anneliese O. Speak,Wendy N. Erber,Augusto Rendon,Willem H. Ouwehand,Willem H. Ouwehand,Cedric Ghevaert +15 more
TL;DR: It is demonstrated that α-granule deficiency impairs platelet function beyond their purely hemostatic role and that Nbeal2 deficiency has a protective effect against cancer metastasis.
Journal ArticleDOI
PDGFRB Promotes Liver Metastasis Formation of Mesenchymal-Like Colorectal Tumor Cells
Ernst J.A. Steller,Danielle A.E. Raats,Jan Koster,Bert Rutten,Klaas M. Govaert,Benjamin L. Emmink,Nikol Snoeren,Sander R. van Hooff,Frank C. P. Holstege,Coen Maas,Inne H.M. Borel Rinkes,Onno Kranenburg +11 more
TL;DR: It is suggested that PDGFRB may contribute to the aggressive phenotype of colorectal tumors with mesenchymal properties, most likely downstream of platelet activation and TGFB signaling.
Journal ArticleDOI
A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis
Ai Takemoto,Mina Okitaka,Mina Okitaka,Satoshi Takagi,Miho Takami,Shigeo Sato,Makoto Nishio,Sakae Okumura,Naoya Fujita,Naoya Fujita +9 more
TL;DR: It is suggested that blocking the TGF-β signalling pathway might be a promising strategy for suppressing podoplanin-mediated haematogenous metastasis in vivo.
Journal ArticleDOI
Role of tumor-derived exosomes in cancer metastasis.
TL;DR: This chapter seeks to explore in-depth the mechanisms engendering TDE in the metastatic cascade, along with experimental models to augment the authors' understanding, and examines potential anti-metastatic therapeutic opportunities derived from exosomal research.
Journal ArticleDOI
Challenges and promises for the development of donor-independent platelet transfusions.
Michele P. Lambert,Michele P. Lambert,Spencer K. Sullivan,Rudy Fuentes,Deborah L. French,Deborah L. French,Mortimer Poncz,Mortimer Poncz +7 more
TL;DR: This review summarizes the current, state-of-the-art methodologies in delivering a clinically relevant ex vivo-derived platelet product, and it discusses significant challenges that must be overcome for this approach to become a clinical reality.
References
More filters
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.