Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer
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RhoG Protein Regulates Platelet Granule Secretion and Thrombus Formation in Mice
Robert Goggs,Matthew T. Harper,Robert J P Pope,Joshua Savage,Christopher Williams,Stuart J. Mundell,Kate J. Heesom,Mark D. Bass,Harry Mellor,Alastair W. Poole +9 more
TL;DR: It is shown that RhoG is expressed in human and mouse platelets and is activated by both collagen-related peptide (CRP) and thrombin stimulation and Interestingly, tail bleeding times were normal in RhoGs−/− mice, suggesting that the functions of Rho GTPases in platelets are particularly relevant to thrombotic disorders.
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The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions
Zoltan Nagy,Timo Vögtle,Mitchell J. Geer,Jun Mori,Silke Heising,Giada Di Nunzio,Ralph Gareus,Alexander Tarakhovsky,Arthur Weiss,Benjamin G. Neel,Guillaume E. Desanti,Alexandra Mazharian,Yotis A. Senis +12 more
TL;DR: A Gp1ba-Cre transgenic mouse strain is developed in which Cre expression is driven by the endogenous Gp 1ba locus, and will advance understanding of the role of platelets in inflammation and other pathophysiological processes in which platelet-leukocyte interactions are involved.
References
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