Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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Emerging Biological Principles of Metastasis
TL;DR: The cellular and molecular mechanisms involved in metastasis are summarized, with a focus on carcinomas where the most is known, and the general principles of metastasis that have begun to emerge are highlighted.
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Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
TL;DR: It is shown that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis and inhibit NF-κB signaling in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo.
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Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado,Haiying Zhang,Irina Matei,Bruno Costa-Silva,Ayuko Hoshino,Gonçalo Rodrigues,Gonçalo Rodrigues,Bethan Psaila,Rosandra N. Kaplan,Jacqueline Bromberg,Yibin Kang,Mina J. Bissell,Thomas R. Cox,Amato J. Giaccia,Janine T. Erler,Sachie Hiratsuka,Cyrus M. Ghajar,David Lyden,David Lyden +18 more
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
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The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
References
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Platelet functions and clinical effects in acute myelogenous leukemia
Brynjar Foss,Øystein Bruserud +1 more
TL;DR: In this review, platelet interactions with normal leukocytes, normal hematopoietic and leukemic cells and the possible clinical relevance of these interactions in AML are described.
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Platelet activation and platelet lipid composition in pulmonary cancer
Domenico Prisco,Rita Paniccia,Mirella Coppo,M. Filippini,Isa Francalanci,Tamara Brunelli,Paolo Comeglio,Rosanna Abbate +7 more
TL;DR: It is concluded that platelet lipid changes could cooperate in platelet activation and increased thrombotic risk so frequently observed in neoplastic disease.
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Role of α4β1 Integrins in Chemokine-Induced Monocyte Arrest under Conditions of Shear Stress
TL;DR: Using soluble ligand‐binding assays and adhesion assays in parallel‐plate flow chambers, critical signaling mediators in chemokine‐induced α4β1 integrin affinity upregulation and monocyte arrest have been identified, including phospholipase C, calcium, and calmodulin.
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The importance of 5‐HT for tumor cell lodgement in the liver
TL;DR: 5‐HT is one of the sub‐stances released from activated platelets and that 5‐ HT is involved in tumor cell lodgement in the liver after intraportal injection of fibrosarcoma cells is indicated.