Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins
Jun Xu,Steve S. Lee,Howon Seo,Liang Pang,Yearin Jun,Ruo Yu Zhang,Zhong Yin Zhang,Pilhan Kim,Wooin Lee,Stephen J. Kron,Yoon Yeo +10 more
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Platelet Derived Biomaterials for Therapeutic Use: Review of Technical Aspects
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TL;DR: This paper reviews the evolution and type of platelet derived biomaterial (platelet rich plasma) consisting of plasma proteins and platelets available for clinical use and the scientific rational and technical aspects in preparation in order to administer them in various fields of medicine.
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Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics.
Quirino Lai,Alessandro Vitale,Tommaso Maria Manzia,Francesco Giuseppe Foschi,Giovanni Battista Levi Sandri,Martina Gambato,F. Melandro,Francesco Paolo Russo,Luca Miele,Luca Viganò,Patrizia Burra,Edoardo G. Giannini +11 more
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Association Between Aspirin Use and Biliary Tract Cancer Survival
Sarah S. Jackson,Ruth M. Pfeiffer,Zhiwei Liu,Lesley A. Anderson,Huei Ting Tsai,Huei Ting Tsai,Shahinaz M. Gadalla,Jill Koshiol +7 more
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Tumor-educated platelet as liquid biopsy in lung cancer patients.
TL;DR: T tumor-educated platelet has the potential to be used as liquid biopsy for a variety of clinical and investigational applications and offers opportunities to detect resistance mechanisms at an early stage.
References
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