Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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The systemic immune-inflammation index is an independent predictor of survival for metastatic colorectal cancer and its association with the lymphocytic response to the tumor.
Qiankun Xie,Ping Chen,Wan-Ming Hu,Wan-Ming Hu,Peng Sun,Wenzhuo He,Chang Jiang,Pengfei Kong,Shousheng Liu,Hai-Tian Chen,Yuan-Zhong Yang,Dan Wang,Lin Yang,Liangping Xia +13 more
TL;DR: A high SII value independently predicts poor clinical outcomes among patients with metastatic colorectal cancer and combining the lymphocytic response to the tumor and SII could further enhance prognostication for mCRC.
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Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma.
TL;DR: Elevated preoperative PLR as an independent prognostic factor is superior to NLR in predicting clinical outcome in patients with STS, providing a new and valuable clue for diagnosing and monitoring STS.
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Platelet-lymphocyte ratio acts as an indicator of poor prognosis in patients with breast cancer.
TL;DR: It is revealed that PLR could serve as an indicator of poor prognosis in patients with breast cancer.
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Role of Aspirin in Breast Cancer Survival.
TL;DR: The current epidemiologic and clinical trial evidence as well as possible underlying mechanisms that justify current phase III randomized trials of aspirin to improve breast cancer survival are summarized.
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Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1.
Laura Amo,Estíbaliz Tamayo-Orbegozo,Natalia Maruri,Cristina Eguizabal,Olatz Zenarruzabeitia,Marta Riñón,Arantza Arrieta,Silvia Santos,Jorge Monge,Miguel Angel Vesga,Francisco Borrego,Susana Larrucea +11 more
TL;DR: The identification of selectin ligands involved in the interaction of platelets with tumor cells may provide help for the development of effective therapies to restrain cancer cell dissemination.
References
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TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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