Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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Emerging Biological Principles of Metastasis
TL;DR: The cellular and molecular mechanisms involved in metastasis are summarized, with a focus on carcinomas where the most is known, and the general principles of metastasis that have begun to emerge are highlighted.
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Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
TL;DR: It is shown that platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis and inhibit NF-κB signaling in cancer cells, resulting in their transition to an invasive mesenchymal-like phenotype and enhanced metastasis in vivo.
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Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado,Haiying Zhang,Irina Matei,Bruno Costa-Silva,Ayuko Hoshino,Gonçalo Rodrigues,Gonçalo Rodrigues,Bethan Psaila,Rosandra N. Kaplan,Jacqueline Bromberg,Yibin Kang,Mina J. Bissell,Thomas R. Cox,Amato J. Giaccia,Janine T. Erler,Sachie Hiratsuka,Cyrus M. Ghajar,David Lyden,David Lyden +18 more
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
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The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
References
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Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor
H.K. Kim,Kyoung-Ju Song,Yangsoon Park,Y.H. Kang,Y.J. Lee,K.R. Lee,K.W. Ryu,J.M. Bae,Soo-Nyung Kim +8 more
TL;DR: Plasma levels of PMP, VEGF, IL-6 and RANTES were markedly increased in patients with stage IV disease, and it is demonstrated that these increased plasma levels of IL- 6, RantES, and especially PMP might be useful for identifying metastatic gastric patients.
Journal ArticleDOI
Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.
TL;DR: Cell surface expression of functional TF contributes to melanoma progression by allowing metastatic cells to provide requisite signals for prolonged adhesive interactions and/or transmigration of tumor cells across the endothelium, resulting in successful metastatic tumor implantation.
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Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity
TL;DR: It is shown that platelet-derived soluble factors, secreted on coating of tumor cells or after stimulation with classic platelet agonists, impair NK cell antitumor reactivity resulting in diminished granule mobilization, cytotoxicity, and IFN-gamma production, and therapeutic intervention in tumor cell-platelet interaction and the resulting TGF-beta release by platelets may serve to enhance antitumors immunity.
Journal Article
Microparticle-associated tissue factor activity: A link between cancer and thrombosis?
M. E. T. Tesselaar,Fred P.H.T.M. Romijn,Irma K. van der Linden,Frans Prins,Rogier M. Bertina,Susanne Osanto +5 more
TL;DR: An important role is suggested for MP‐associated TF and MUC1 in the pathogenesis of thrombosis in disseminated mucinous adenocarcinoma patients.
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Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis.
Eric Camerer,Aisha A. Qazi,Daniel N. Duong,Ivo Cornelissen,Rommel Advincula,Shaun R. Coughlin +5 more
TL;DR: Genetic evidence is provided that platelets play a key role in hematogenous metastasis and contribute to this process by both thrombin-dependent and -independent mechanisms.