Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Journal ArticleDOI
Anti-platelet treatments in cancer: Basic and clinical research.
TL;DR: An overview of the platelet-targeted pharmacologic approaches that have been attempted in the prevention of cancer development, progression and metastasis, including the application of antiplatelet drugs currently used for cardiovascular disease and of new and novel strategies.
Journal ArticleDOI
The effect of warfarin therapy on breast, colorectal, lung, and prostate cancer survival: a population-based cohort study using the Clinical Practice Research Datalink
TL;DR: Dose–response analyses did not reveal consistent evidence of reductions in users of warfarin defined by the number of prescriptions used and daily defined doses, and there was little evidence of associations between pre-diagnostic use of warFarin and cancer-specific mortality in lung, prostate, breast, or colorectal cancer patients.
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A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer.
Ke Zhang,Hui Feng Gao,Miao Mo,Cai Jun Wu,Yong Qiang Hua,Zhen Chen,Zhiqiang Meng,Lu Ming Liu,Hao Chen +8 more
TL;DR: PT, FBG and MPV were independent prognostic factors in advanced pancreatic cancer and a novel scoring system based on these hemostatic parameters could be used to predict the survival of patients with advanced Pancreatic cancer.
Book ChapterDOI
Breast Cancer Metastasis.
TL;DR: In this paper, the authors discuss recent discovery and advances in the field of breast cancer metastasis research, and discuss the major players and molecules in this process, which is mainly attributed to the complexity of metastatic process.
Journal ArticleDOI
The preoperative platelet to albumin ratio predicts the prognosis of hepatocellular carcinoma patients without portal hypertension after liver resection.
TL;DR: The PAR may be a useful marker to predict the prognosis of HCC patients after liver resection with a higher recurrent risk and lower long-term survival rate than those with a low preoperative PAR.
References
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Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.