Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application.
TL;DR: Examples of snake venom components which have spurred the development of novel pharmaceutical compounds are given, especially in the fields of hemostasis, thrombosis, coagulation, and metastasis, to help in influencing a specific body function pharmaceutically.
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Platelets contribute to the initiation of colitis-associated cancer by promoting immunosuppression.
Laurence Servais,Odile Wéra,J. Dibato Epoh,Céline Delierneux,Nassim Bouznad,Souad Rahmouni,Gabriel Mazzucchelli,Dominique Baiwir,Philippe Delvenne,Patrizio Lancellotti,Cécile Oury +10 more
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Do aspirin and other NSAIDs confer a survival benefit in men diagnosed with prostate cancer? A pooled analysis of NIH-AARP and PLCO cohorts
Cindy Ke Zhou,Sarah E. Daugherty,Linda M. Liao,Neal D. Freedman,Christian C. Abnet,Ruth M. Pfeiffer,Michael B. Cook +6 more
TL;DR: It is suggested that aspirin or non-aspirin NSAIDs are not associated with prostate cancer survival, however, aspirin use both before and after prostate cancer diagnosis was associated with longer overall survival, highlighting the importance of comorbidity prevention among prostate cancer survivors.
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Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP.
Tatiana F. Ottaiano,Sheila Siqueira Andrade,Cleide de Oliveira,Mariana Cristina Cabral Silva,Marcus V. Buri,Maria A. Juliano,Manoel João Batista Castello Girão,Misako U. Sampaio,Alvin H. Schmaier,Alexander Wlodawer,Francisco Humberto de Abreu Maffei,Maria Luiza Vilela Oliva +11 more
TL;DR: The results suggest a new function for huPK, consistent with the notion that plasma kallikrein promotes vascular disease and thrombosis in the intravascular compartment and its inhibition may ameliorate cardiovascular disease and THROMbosis.
Journal ArticleDOI
Platelet Metabolism and Other Targeted Drugs; Potential Impact on Immunotherapy.
Preeti Kanikarla-Marie,Michael Lam,Alexey V. Sorokin,Michael J. Overman,Scott Kopetz,David G. Menter +5 more
TL;DR: The importance of platelets in tumor progression, therapeutic response, survival, and the notion of immunotherapy modulation being likely to benefit from the inclusion of platelet inhibitors are summarized.
References
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