Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Hematologic variables associated with brain failure in patients with small-cell lung cancer.
TL;DR: High PPC was associated with increased rates of brain metastasis in patients with SCLC with no evidence of brain disease at diagnosis, and the two-year BMFS rates were worse for patients with high PPC.
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The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer
TL;DR: In this article, the authors evaluated the association of preoperative platelet counts and plasma fibrinogen levels with postoperative lymph node involvement and venous invasion in colorectal cancer patients.
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The Provocative Roles of Platelets in Liver Disease and Cancer.
Preeti Kanikarla Marie,Natalie W. Fowlkes,Vahid Afshar-Kharghan,Stephanie L. Martch,Alexey V. Sorokin,John Paul Shen,Van K. Morris,Arvind Dasari,Nancy You,Anil K. Sood,Michael J. Overman,Scott Kopetz,David G. Menter +12 more
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Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer
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Prognostic Dynamic Nomogram Integrated with Inflammation-Based Factors for Non-Small Cell Lung Cancer Patients with Chronic Hepatitis B Viral Infection
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