Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
More filters
Journal ArticleDOI
Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics
TL;DR: In this paper , the authors systematically summarize the superior functions of various cell membrane camouflaged NPs in tumor imaging, especially highlighting the advanced applications in different imaging techniques, which is to provide the theoretical supports for the development of precise guided imaging and tumor treatment.
Journal ArticleDOI
Platelets in cancer development and diagnosis.
Annalisa Contursi,Rosalia Grande,Melania Dovizio,Annalisa Bruno,Rosa Fullone,Paola Patrignani +5 more
TL;DR: The evaluation of proteomics and transcriptomics signature of platelets and platelet-derived microparticles could represent a new strategy for the development of biomarkers for early cancer detection and/or therapeutic drug monitoring in cancer chemotherapy.
Journal ArticleDOI
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer.
TL;DR: This review summarises recent advances in the field of CTC research with focus on technical and biological challenges as well the progress made towards clinical utility of characterisation of C TCs with emphasis on studies in lung cancer.
Journal ArticleDOI
Lymphocyte-to-monocyte ratio effectively predicts survival outcome of patients with obstructive colorectal cancer.
TL;DR: Preoperative dNLR and LMR could predict OS and DFS in patients undergoing ES and BTS, respectively, and for OCC, as the potential benefit group, patients with a low LMR might be preferred for BTS via SEMS insertion.
Journal ArticleDOI
Aspirin and antiplatelet treatments in cancer.
TL;DR: In this paper, the authors present a review of the platelet binding, activation, and count as potential mitigating agents in cancer development and metastasis, and present an overview of clinical cancer prevention and outcome studies with lowdose aspirin.
References
More filters
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.