Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
More filters
Journal ArticleDOI
Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model.
Chuan Wang,Ying Ge Chen,Jian-Li Gao,Gui‑Yuan Lyu,Jie Su,Qi Zhang,Xin Ji,Ji-Zhong Yan,Qiao‑Li Qiu,Yue‑Li Zhang,Lin‑Zi Li,Han‑Ting Xu,Su‑Hong Chen +12 more
TL;DR: The results of the present study demonstrated that tumor growth led to thrombosis and acute anemia in mice; in addition, when blood BASO% was low, an increased number of lung metastases were observed in tumor-bearing mice.
Journal ArticleDOI
Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer
Ashley R. Rowson-Hodel,Jessica H. Wald,Jason Hatakeyama,Wanda K. O'Neal,Jaclyn R. Stonebraker,Kacey VanderVorst,Matthew Saldana,Alexander D. Borowsky,Colleen A Sweeney,Kermit L. Carraway +9 more
TL;DR: Together, the observations suggest that Muc4 may facilitate metastasis by promoting the association of circulating tumor cells with blood cells to augment tumor cell survival in circulation.
Journal ArticleDOI
The effect of anaesthetic technique during primary breast cancer surgery on neutrophil–lymphocyte ratio, platelet–lymphocyte ratio and return to intended oncological therapy
TL;DR: The primary hypothesis was that postoperative neutrophil–lymphocyte ratio is lower in patients allocated to receive propofol‐paravertebral rather than inhalational agent‐opioid anaesthesia for primary breast cancer surgery.
Journal ArticleDOI
Pretreatment thrombocytosis as a prognostic factor in metastatic breast cancer.
TL;DR: Thrombocytosis represents an independent adverse prognostic factor in patients with metastatic breast cancer, and it joins a range of cancers in which this easily measurable value can be used for clinical prognostication.
Journal ArticleDOI
Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis.
Olivier Boutaud,I. Romina Sosa,I. Romina Sosa,Taneem Amin,Denise Oram,David H. Adler,Hyun Seok Hwang,Brenda C. Crews,Ginger L. Milne,Bradford K. Harris,Megan D. Hoeksema,Bjorn C. Knollmann,Philip E. Lammers,Philip E. Lammers,Lawrence J. Marnett,Pierre P. Massion,John A. Oates +16 more
TL;DR: Low-dose aspirin has a significant effect on extraplatelet cyclooxygenase and potently inhibits COX-2 in lung and colon adenocarcinoma cells, and this supports a hypothesis that the remarkable prevention of metastasis from adenOCarcinomas, and particularly from colon adnocarc inomas, by low- dose aspirin results from its effect on platelet COX1 combined with inhibition of PGE2 biosynthesis in metastasizing tumor cells.
References
More filters
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
Journal ArticleDOI
Dissemination and growth of cancer cells in metastatic sites
TL;DR: Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy and could help to improve the treatment of metastatic disease.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Integrins in cancer: biological implications and therapeutic opportunities
TL;DR: Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.