Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress
TL;DR: The fluid-generated forces that tumor cells are exposed to in the vascular and tumor microenvironments are reviewed, and recent computational and experimental models that have revealed mechanotransduction phenomena that may play a role in the metastatic process are discussed.
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Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences.
Soraya Mezouar,Corinne Frere,Roxane Darbousset,Diane Mege,Lydie Crescence,Françoise Dignat-George,Laurence Panicot-Dubois,Christophe Dubois +7 more
TL;DR: The interesting contribution of platelets to cancer and cancer-associated thrombosis requires the standardization of preclinical and clinical models.
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Antitumor Platelet‐Mimicking Magnetic Nanoparticles
Lang Rao,Lin-Lin Bu,Qian-Fang Meng,Bo Cai,Wei-Wei Deng,Andrew Li,Kaiyang Li,Shishang Guo,Wen-Feng Zhang,Wei Liu,Zhi-Jun Sun,Xing-Zhong Zhao +11 more
TL;DR: An all‐in‐one nanoplatform possessed with long circulation and cancer targeting capabilities for personalized cancer theranostics is fabricated and PLT‐MNs exhibit stellar immune compatibility.
Journal ArticleDOI
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Monika Haemmerle,Monika Haemmerle,Morgan Taylor,Tony Gutschner,Tony Gutschner,Sunila Pradeep,Min Soon Cho,Jianting Sheng,Yasmin M. Lyons,Archana S. Nagaraja,R.L. Dood,Yunfei Wen,Lingegowda S. Mangala,Jean M. Hansen,Rajesha Rupaimoole,Kshipra M. Gharpure,Cristian Rodriguez-Aguayo,Sun Young Yim,Ju Seog Lee,Cristina Ivan,Wei Hu,Gabriel Lopez-Berestein,Stephen T. C. Wong,Beth Y. Karlan,Douglas A. Levine,Jinsong Liu,Vahid Afshar-Kharghan,Anil K. Sood +27 more
TL;DR: It is demonstrated that platelets induce resistance to anoikis in vitro and are critical for metastasis in vivo, and reduction of YAP1 in cancer cells in vivo protects against thrombocytosis-induced increase in metastasis.
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Targeted Nanotechnology for Cancer Imaging
TL;DR: This review seeks to illustrate that the design of a nanoparticle dictates its in vivo journey and targeting of hard-to-reach cancer sites, facilitating early and accurate diagnosis and interrogation of the most aggressive forms of cancer.
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