Contribution of platelets to tumour metastasis.
TLDR
Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.Abstract:
Experimental evidence suggests that platelets contribute to metastasis through adhesive and haemostatic functions that promote cancer cell survival, immune evasion and interactions with vascular cells to assist organ colonization from the bloodstream. Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.read more
Citations
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Platelet count is associated with cardiovascular disease, cancer and mortality: A population-based cohort study
Pernille Just Vinholt,Anne-Mette Hvas,Henrik Frederiksen,Lise Bathum,M.K. Jørgensen,Mads Nybo +5 more
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Exercise-induced biochemical changes and their potential influence on cancer: a scientific review
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A novel and essential role for FcγRIIa in cancer cell–induced platelet activation
TL;DR: It is demonstrated that cancer cells can promote platelet dense-granule secretion, which is required to augment platelet aggregation, and shows a novel essential role for FcγRIIa in prostate cancer cell-induced platelet activation opening the opportunity to develop novel antimetastatic therapies.
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Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment.
TL;DR: This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies.
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Targeting myeloid cells in the tumor sustaining microenvironment.
Jonathan Schupp,Franziska K. Krebs,Franziska K. Krebs,Niklas Zimmer,Emily Trzeciak,Detlef Schuppan,Andrea Tuettenberg +6 more
TL;DR: This work provides an introduction into current and novel therapeutic approaches to redirect myeloid cells from a cancer promoting to a rather inflammatory, cancer inhibiting phenotype and the role of platelets for tumor promotion is discussed.
References
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